eprintid: 10098308 rev_number: 22 eprint_status: archive userid: 608 dir: disk0/10/09/83/08 datestamp: 2020-05-27 14:02:54 lastmod: 2022-04-04 12:39:09 status_changed: 2022-04-04 12:39:09 type: article metadata_visibility: show creators_name: Maksymowych, WP creators_name: Pedersen, SJ creators_name: Weber, U creators_name: Baraliakos, X creators_name: Machado, PM creators_name: Eshed, I creators_name: De Hooge, M creators_name: Sieper, J creators_name: Wichuk, S creators_name: Rudwaleit, M creators_name: Van der Heijde, D creators_name: Landewé, RBM creators_name: Poddubnyy, D creators_name: Ostergaard, M creators_name: Lambert, RGW title: Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort: discrepancies with local readers and impact on the performance of the ASAS criteria ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F85 note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: OBJECTIVES: The Assessment of SpondyloArthritis international Society (ASAS) MRI working group conducted a multireader exercise on MRI scans from the ASAS classification cohort to assess the spectrum and evolution of lesions in the sacroiliac joint and impact of discrepancies with local readers on numbers of patients classified as axial spondyloarthritis (axSpA). METHODS: Seven readers assessed baseline scans from 278 cases and 8 readers assessed baseline and follow-up scans from 107 cases. Agreement for detection of MRI lesions between central and local readers was assessed descriptively and by the kappa statistic. We calculated the number of patients classified as axSpA by the ASAS criteria after replacing local detection of active lesions by central readers and replacing local reader radiographic sacroiliitis by central reader structural lesions on MRI. RESULTS: Structural lesions, especially erosions, were as frequent as active lesions (≈40%), the majority of patients having both types of lesions. The ASAS definitions for active MRI lesion typical of axSpA and erosion were comparatively discriminatory between axSpA and non-axSpA. Local reader overcall for active MRI lesions was about 30% but this had a minor impact on the number of patients (6.4%) classified as axSpA. Substitution of radiography with MRI structural lesions also had little impact on classification status (1.4%). CONCLUSION: Despite substantial discrepancy between central and local readers in interpretation of both types of MRI lesion, this had a minor impact on the numbers of patients classified as axSpA supporting the robustness of the ASAS criteria for differences in assessment of imaging. date: 2020-06-14 date_type: published official_url: https://doi.org/10.1136/annrheumdis-2020-217232 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1782043 doi: 10.1136/annrheumdis-2020-217232 pii: annrheumdis-2020-217232 lyricists_name: Machado, Pedro lyricists_id: PMMAC99 actors_name: Machado, Pedro actors_id: PMMAC99 actors_role: owner full_text_status: public publication: Annals of the Rheumatic Diseases volume: 79 pagerange: 935-942 event_location: England citation: Maksymowych, WP; Pedersen, SJ; Weber, U; Baraliakos, X; Machado, PM; Eshed, I; De Hooge, M; ... Lambert, RGW; + view all <#> Maksymowych, WP; Pedersen, SJ; Weber, U; Baraliakos, X; Machado, PM; Eshed, I; De Hooge, M; Sieper, J; Wichuk, S; Rudwaleit, M; Van der Heijde, D; Landewé, RBM; Poddubnyy, D; Ostergaard, M; Lambert, RGW; - view fewer <#> (2020) Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort: discrepancies with local readers and impact on the performance of the ASAS criteria. Annals of the Rheumatic Diseases , 79 pp. 935-942. 10.1136/annrheumdis-2020-217232 <https://doi.org/10.1136/annrheumdis-2020-217232>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10098308/3/Machado_Manuscript%202%20v14-clean.pdf