<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10097595> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/title> "An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/abstract> "Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology at the earliest stage of some neurodegenerative disorders, but do not have the scalability needed for population screening. Therefore, a blood-based marker for such pathophysiology would have greater utility in a primary care setting and in eligibility screening for clinical trials. Rapid advances in ultra-sensitive assays have enabled the levels of pathological proteins to be measured in blood samples, but research has been predominantly focused on Alzheimer disease (AD). Nonetheless, proteins that were identified as potential blood-based biomarkers for AD, for example, amyloid-β, tau, phosphorylated tau and neurofilament light chain, are likely to be relevant to other neurodegenerative disorders that involve similar pathological processes and could also be useful for the differential diagnosis of clinical symptoms. This Review outlines the neuropathological, clinical, molecular imaging and cerebrospinal fluid features of the most common neurodegenerative disorders outside the AD continuum and gives an overview of the current status of blood-based biomarkers for these disorders."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/date> "2020-03" . <https://discovery.ucl.ac.uk/id/document/1103645> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/volume> "16" . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/issue> "5" . <https://discovery.ucl.ac.uk/id/org/ext-1c63d9cb7ce409aca2e1962714982576> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Organization> . <https://discovery.ucl.ac.uk/id/org/ext-1c63d9cb7ce409aca2e1962714982576> 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<https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-41a23cd5b7ce276ce04040b3a2810e8b> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6eb2ddcfa195a2300e9ee1274aa64a3e> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-6eb2ddcfa195a2300e9ee1274aa64a3e> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3f36739d246129e6e0b5d7c9179e42d1> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-3f36739d246129e6e0b5d7c9179e42d1> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5de49e79feb3315b28f721327d047368> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-5de49e79feb3315b28f721327d047368> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fb2e10bb7e99d80d4bc170050bd642b7> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-fb2e10bb7e99d80d4bc170050bd642b7> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ae2d31c9f884274c92e64c342c6ae3ea> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-ae2d31c9f884274c92e64c342c6ae3ea> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ac3b3373913ac68bef51638b90a9bc0f> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-ac3b3373913ac68bef51638b90a9bc0f> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-21bb42679fad39a7246b3d2b2175fe46> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-21bb42679fad39a7246b3d2b2175fe46> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-71d334d1825fd40545abe56bfa4d644d> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-71d334d1825fd40545abe56bfa4d644d> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9568d21e237212be75d108621e1c89a5> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-9568d21e237212be75d108621e1c89a5> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8e19383c9b65d4bbd00d82d29ac66a2f> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-8e19383c9b65d4bbd00d82d29ac66a2f> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6af7dee15a23e6d999835a10d5c7f956> . <https://discovery.ucl.ac.uk/id/eprint/10097595> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> . <https://discovery.ucl.ac.uk/id/eprint/10097595#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_17> <https://discovery.ucl.ac.uk/id/person/ext-6af7dee15a23e6d999835a10d5c7f956> . <https://discovery.ucl.ac.uk/id/person/ext-8e19383c9b65d4bbd00d82d29ac66a2f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8e19383c9b65d4bbd00d82d29ac66a2f> <http://xmlns.com/foaf/0.1/givenName> "H"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8e19383c9b65d4bbd00d82d29ac66a2f> <http://xmlns.com/foaf/0.1/familyName> "Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8e19383c9b65d4bbd00d82d29ac66a2f> <http://xmlns.com/foaf/0.1/name> "H Zetterberg"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6eb2ddcfa195a2300e9ee1274aa64a3e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-6eb2ddcfa195a2300e9ee1274aa64a3e> <http://xmlns.com/foaf/0.1/givenName> "TK"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6eb2ddcfa195a2300e9ee1274aa64a3e> <http://xmlns.com/foaf/0.1/familyName> "Karikari"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-6eb2ddcfa195a2300e9ee1274aa64a3e> <http://xmlns.com/foaf/0.1/name> "TK Karikari"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-36b20b01b33e7f119b1fcacc24d490c5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-36b20b01b33e7f119b1fcacc24d490c5> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-36b20b01b33e7f119b1fcacc24d490c5> <http://xmlns.com/foaf/0.1/familyName> "Snowden"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-36b20b01b33e7f119b1fcacc24d490c5> <http://xmlns.com/foaf/0.1/name> "S Snowden"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-21bb42679fad39a7246b3d2b2175fe46> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-21bb42679fad39a7246b3d2b2175fe46> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-21bb42679fad39a7246b3d2b2175fe46> <http://xmlns.com/foaf/0.1/familyName> "Hortobagyi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-21bb42679fad39a7246b3d2b2175fe46> <http://xmlns.com/foaf/0.1/name> "T Hortobagyi"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ac3b3373913ac68bef51638b90a9bc0f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ac3b3373913ac68bef51638b90a9bc0f> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ac3b3373913ac68bef51638b90a9bc0f> <http://xmlns.com/foaf/0.1/familyName> "Ballard"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ac3b3373913ac68bef51638b90a9bc0f> <http://xmlns.com/foaf/0.1/name> "C Ballard"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ae2d31c9f884274c92e64c342c6ae3ea> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-ae2d31c9f884274c92e64c342c6ae3ea> <http://xmlns.com/foaf/0.1/givenName> "K"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ae2d31c9f884274c92e64c342c6ae3ea> <http://xmlns.com/foaf/0.1/familyName> "Hoglund"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-ae2d31c9f884274c92e64c342c6ae3ea> <http://xmlns.com/foaf/0.1/name> "K Hoglund"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-5de49e79feb3315b28f721327d047368> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . 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