eprintid: 10097376 rev_number: 17 eprint_status: archive userid: 608 dir: disk0/10/09/73/76 datestamp: 2020-05-14 10:09:54 lastmod: 2021-12-05 01:05:21 status_changed: 2020-05-14 10:09:54 type: article metadata_visibility: show creators_name: Seddon, JA creators_name: Wilkinson, R creators_name: van Crevel, R creators_name: Figaji, A creators_name: Thwaites, GE creators_name: Aarnoutse, RE creators_name: Anderson, STB creators_name: Bahr, NC creators_name: Bang, ND creators_name: Boulware, DR creators_name: Boyles, T creators_name: te Brake, LHM creators_name: Chandra, S creators_name: Chow, FC creators_name: Cresswell, FV creators_name: Davis, AG creators_name: Dian, S creators_name: Donovan, J creators_name: Dooley, KE creators_name: Rizal, AG creators_name: Garg, RK creators_name: Gibb, DM creators_name: Hamers, RL creators_name: Hiep, NTT creators_name: Imran, D creators_name: Imron, A creators_name: Jain, SK creators_name: Jain, SK creators_name: Jeejeebhoy, B creators_name: Kalita, J creators_name: Kumar, R creators_name: Kumar, V creators_name: van Laarhoven, A creators_name: Lai, RPJ creators_name: Manesh, A creators_name: Marais, S creators_name: Mave, V creators_name: Meintjes, G creators_name: Meya, DB creators_name: Misra, UK creators_name: Modi, M creators_name: Ordonez, AA creators_name: Phu, NH creators_name: Pradhan, S creators_name: Prasad, K creators_name: Proust, AM creators_name: Ramakrishnan, L creators_name: Rohlwink, U creators_name: Ruslami, R creators_name: Schoeman, JF creators_name: Sharma, K creators_name: Siddiqi, O creators_name: Solomons, RS creators_name: Thuong, NTT creators_name: van Toorn, R creators_name: Tucker, EW creators_name: Wasserman, SA creators_name: Wilkinson, RJ title: Knowledge gaps and research priorities in tuberculous meningitis [version 1; peer review: 3 approved] ispublished: pub divisions: UCL divisions: B02 divisions: D65 divisions: J38 keywords: Tuberculosis, Tuberculous Meningitis, Research Priorities, Epidemiology, Diagnosis, Treatment, Critical Care, Care Cascade note: © 2019 Seddon JA et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: Tuberculous meningitis (TBM) is the most severe and disabling form of tuberculosis (TB), accounting for around 1-5% of the global TB caseload, with mortality of approximately 20% in children and up to 60% in persons co-infected with human immunodeficiency virus even in those treated. Relatively few centres of excellence in TBM research exist and the field would therefore benefit from greater co-ordination, advocacy, collaboration and early data sharing. To this end, in 2009, 2015 and 2019 we convened the TBM International Research Consortium, bringing together approximately 50 researchers from five continents. The most recent meeting took place on 1st and 2nd March 2019 in Lucknow, India. During the meeting, researchers and clinicians presented updates in their areas of expertise, and additionally presented on the knowledge gaps and research priorities in that field. Discussion during the meeting was followed by the development, by a core writing group, of a synthesis of knowledge gaps and research priorities within seven domains, namely epidemiology, pathogenesis, diagnosis, antimicrobial therapy, host-directed therapy, critical care and implementation science. These were circulated to the whole consortium for written input and feedback. Further cycles of discussion between the writing group took place to arrive at a consensus series of priorities. This article summarises the consensus reached by the consortium concerning the unmet needs and priorities for future research for this neglected and often fatal disease. date: 2019-11-28 date_type: published official_url: https://doi.org/10.12688/wellcomeopenres.15573.1 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1781085 doi: 10.12688/wellcomeopenres.15573.1 lyricists_name: Gibb, Diana lyricists_id: MGIBB48 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Wellcome Open Research volume: 4 article_number: 188 citation: Seddon, JA; Wilkinson, R; van Crevel, R; Figaji, A; Thwaites, GE; Aarnoutse, RE; Anderson, STB; ... Wilkinson, RJ; + view all <#> Seddon, JA; Wilkinson, R; van Crevel, R; Figaji, A; Thwaites, GE; Aarnoutse, RE; Anderson, STB; Bahr, NC; Bang, ND; Boulware, DR; Boyles, T; te Brake, LHM; Chandra, S; Chow, FC; Cresswell, FV; Davis, AG; Dian, S; Donovan, J; Dooley, KE; Rizal, AG; Garg, RK; Gibb, DM; Hamers, RL; Hiep, NTT; Imran, D; Imron, A; Jain, SK; Jain, SK; Jeejeebhoy, B; Kalita, J; Kumar, R; Kumar, V; van Laarhoven, A; Lai, RPJ; Manesh, A; Marais, S; Mave, V; Meintjes, G; Meya, DB; Misra, UK; Modi, M; Ordonez, AA; Phu, NH; Pradhan, S; Prasad, K; Proust, AM; Ramakrishnan, L; Rohlwink, U; Ruslami, R; Schoeman, JF; Sharma, K; Siddiqi, O; Solomons, RS; Thuong, NTT; van Toorn, R; Tucker, EW; Wasserman, SA; Wilkinson, RJ; - view fewer <#> (2019) Knowledge gaps and research priorities in tuberculous meningitis [version 1; peer review: 3 approved]. Wellcome Open Research , 4 , Article 188. 10.12688/wellcomeopenres.15573.1 <https://doi.org/10.12688/wellcomeopenres.15573.1>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10097376/1/6bc54c5f-b438-4912-9e8a-f8f6d559bf17_15573_-_james_seddon.pdf