eprintid: 10097105 rev_number: 27 eprint_status: archive userid: 608 dir: disk0/10/09/71/05 datestamp: 2020-05-12 11:47:46 lastmod: 2021-09-23 22:28:36 status_changed: 2020-10-20 06:51:17 type: article metadata_visibility: show creators_name: De Winde, CM creators_name: Munday, C creators_name: Acton, SE title: Molecular mechanisms of dendritic cell migration in immunity and cancer ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D77 note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: Dendritic cells (DCs) are a heterogeneous population of antigen-presenting cells that act to bridge innate and adaptive immunity. DCs are critical in mounting effective immune responses to tissue damage, pathogens and cancer. Immature DCs continuously sample tissues and engulf antigens via endocytic pathways such as phagocytosis or macropinocytosis, which result in DC activation. Activated DCs undergo a maturation process by downregulating endocytosis and upregulating surface proteins controlling migration to lymphoid tissues where DC-mediated antigen presentation initiates adaptive immune responses. To traffic to lymphoid tissues, DCs must adapt their motility mechanisms to migrate within a wide variety of tissue types and cross barriers to enter lymphatics. All steps of DC migration involve cell–cell or cell–substrate interactions. This review discusses DC migration mechanisms in immunity and cancer with a focus on the role of cytoskeletal processes and cell surface proteins, including integrins, lectins and tetraspanins. Understanding the adapting molecular mechanisms controlling DC migration in immunity provides the basis for therapeutic interventions to dampen immune activation in autoimmunity, or to improve anti-tumour immune responses. date: 2020-08 date_type: published publisher: Springer Verlag official_url: https://doi.org/10.1007/s00430-020-00680-4 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1781391 doi: 10.1007/s00430-020-00680-4 lyricists_name: Acton, Sophie lyricists_name: De Winde, Charlotte lyricists_id: SEPIN99 lyricists_id: CMDEW48 actors_name: De Winde, Charlotte actors_id: CMDEW48 actors_role: owner full_text_status: public publication: Medical Microbiology and Immunology volume: 209 pagerange: 515-529 citation: De Winde, CM; Munday, C; Acton, SE; (2020) Molecular mechanisms of dendritic cell migration in immunity and cancer. Medical Microbiology and Immunology , 209 pp. 515-529. 10.1007/s00430-020-00680-4 <https://doi.org/10.1007/s00430-020-00680-4>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10097105/1/De%20Winde_DeWinde2020_Article_MolecularMechanismsOfDendritic.pdf