eprintid: 10096729 rev_number: 26 eprint_status: archive userid: 608 dir: disk0/10/09/67/29 datestamp: 2020-05-05 06:35:10 lastmod: 2021-09-19 23:16:35 status_changed: 2020-05-05 06:35:10 type: article metadata_visibility: show creators_name: Cheong, JLY creators_name: de Pablo-Fernandez, E creators_name: Foltynie, T creators_name: Noyce, AJ title: The Association Between Type 2 Diabetes Mellitus and Parkinson's Disease ispublished: inpress divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 keywords: Parkinson’s disease, epidemiology, mechanisms, therapeutics, type 2 diabetes mellitus note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: In recent years, an emerging body of evidence has forged links between Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with T2DM appear to be at increased risk of developing PD, as well as experiencing faster progression and a more severe phenotype of PD, with the effects being potentially mediated by several common cellular pathways. The insulin signalling pathway, for example, may be responsible for neurodegeneration via affecting insulin dysregulation, aggregation of amyloids, neuroinflammation, mitochondrial dysfunction and altered synaptic plasticity. In light of these potential shared disease mechanisms, clinical trials are now investigating the use of established diabetes drugs targeting insulin resistance in the management of PD. This review will discuss the epidemiological links between T2DM and PD, the potential shared cellular mechanisms, and assess the relevant treatment options for disease modification of PD. date: 2020-04-24 date_type: published official_url: https://doi.org/10.3233/JPD-191900 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1779952 doi: 10.3233/JPD-191900 pii: JPD191900 lyricists_name: De Pablo Fernandez, Eduardo lyricists_name: Foltynie, Thomas lyricists_name: Noyce, Alastair lyricists_id: EDEPA70 lyricists_id: TFOLT83 lyricists_id: NOYCE20 actors_name: Jayawardana, Anusha actors_id: AJAYA51 actors_role: owner full_text_status: public publication: Journal of Parkinson's Disease event_location: Netherlands issn: 1877-718X citation: Cheong, JLY; de Pablo-Fernandez, E; Foltynie, T; Noyce, AJ; (2020) The Association Between Type 2 Diabetes Mellitus and Parkinson's Disease. Journal of Parkinson's Disease 10.3233/JPD-191900 <https://doi.org/10.3233/JPD-191900>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10096729/1/Noyce_jpd-prepress_jpd--1--1-jpd191900_jpd--1-jpd191900.pdf