eprintid: 10096729
rev_number: 26
eprint_status: archive
userid: 608
dir: disk0/10/09/67/29
datestamp: 2020-05-05 06:35:10
lastmod: 2021-09-19 23:16:35
status_changed: 2020-05-05 06:35:10
type: article
metadata_visibility: show
creators_name: Cheong, JLY
creators_name: de Pablo-Fernandez, E
creators_name: Foltynie, T
creators_name: Noyce, AJ
title: The Association Between Type 2 Diabetes Mellitus and Parkinson's Disease
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Parkinson’s disease, epidemiology, mechanisms, therapeutics, type 2 diabetes mellitus
note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: In recent years, an emerging body of evidence has forged links between Parkinson's disease (PD) and type 2 diabetes mellitus (T2DM). In observational studies, those with T2DM appear to be at increased risk of developing PD, as well as experiencing faster progression and a more severe phenotype of PD, with the effects being potentially mediated by several common cellular pathways. The insulin signalling pathway, for example, may be responsible for neurodegeneration via affecting insulin dysregulation, aggregation of amyloids, neuroinflammation, mitochondrial dysfunction and altered synaptic plasticity. In light of these potential shared disease mechanisms, clinical trials are now investigating the use of established diabetes drugs targeting insulin resistance in the management of PD. This review will discuss the epidemiological links between T2DM and PD, the potential shared cellular mechanisms, and assess the relevant treatment options for disease modification of PD.
date: 2020-04-24
date_type: published
official_url: https://doi.org/10.3233/JPD-191900
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1779952
doi: 10.3233/JPD-191900
pii: JPD191900
lyricists_name: De Pablo Fernandez, Eduardo
lyricists_name: Foltynie, Thomas
lyricists_name: Noyce, Alastair
lyricists_id: EDEPA70
lyricists_id: TFOLT83
lyricists_id: NOYCE20
actors_name: Jayawardana, Anusha
actors_id: AJAYA51
actors_role: owner
full_text_status: public
publication: Journal of Parkinson's Disease
event_location: Netherlands
issn: 1877-718X
citation:        Cheong, JLY;    de Pablo-Fernandez, E;    Foltynie, T;    Noyce, AJ;      (2020)    The Association Between Type 2 Diabetes Mellitus and Parkinson's Disease.                   Journal of Parkinson's Disease        10.3233/JPD-191900 <https://doi.org/10.3233/JPD-191900>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10096729/1/Noyce_jpd-prepress_jpd--1--1-jpd191900_jpd--1-jpd191900.pdf