eprintid: 10095184 rev_number: 27 eprint_status: archive userid: 608 dir: disk0/10/09/51/84 datestamp: 2020-04-23 17:12:17 lastmod: 2021-09-18 21:52:19 status_changed: 2020-04-23 17:12:17 type: article metadata_visibility: show creators_name: Alsharif, AA creators_name: Wei, L creators_name: Ma, T creators_name: Man, KKC creators_name: Lau, WCY creators_name: Brauer, R creators_name: Almetwazi, M creators_name: Howard, R creators_name: Wong, ICK title: Prevalence and Incidence of Dementia in People with Diabetes Mellitus ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 divisions: C08 divisions: D10 divisions: G11 keywords: Dementia, THIN database, diabetes mellitus, epidemiology, incidence, prevalence note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: BACKGROUND: Few studies have shown that an increased risk of dementia is associated with diabetes mellitus. OBJECTIVE: To estimate the prevalence and incidence of dementia in people with diabetes in primary care in the UK. METHODS: We conducted a descriptive study using the UK The Health Improvement Network (THIN) database. People diagnosed with diabetes from 2000 to 2016 were included in the study. Prevalence and incidence rates of dementia were calculated annually, stratified by age and gender. RESULTS: The prevalence of dementia was 0.424% [95% CI (0.420%-0.427%)] in 2000 and 2.508% [95% CI (2.501%-2.515%)] in 2016. The highest prevalence was in those aged 85+ from 2.9% [95% CI (2.890%-2.974%)] in 2000 to 11.3% [95% CI (11.285%-11.384%)] in 2016. The incidence of dementia increased 3.7 times, from 0.181 cases per 100 persons [95% CI (0.179-0.183)] in 2000 to 0.683 cases per 100 persons [95% CI (0.679-0.686)] in 2016, respectively. Women had a higher prevalence and incidence of dementia than men 3.138% [95% CI (3.127%-3.150%)] versus 2.014% [95% CI (2.006%-2.022%)] and 0.820 [95% CI (0.814-0.826)] versus 0.576 cases per 100 persons [95% CI (0.571-0.580)] in 2016, respectively. CONCLUSION: There was a trend of increasing prevalence and incidence of dementia in people with diabetes over the period of 2000 to 2016. This study adds to the evidence on dementia prevalence and incidence, particularly in the diabetic population. date: 2020-04-13 date_type: published official_url: https://doi.org/10.3233/JAD-191115 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1777075 doi: 10.3233/JAD-191115 pii: JAD191115 lyricists_name: Alsharif, Alaa lyricists_name: Brauer, Ruth lyricists_name: Howard, Robert lyricists_name: Lau, Cheuk Yin lyricists_name: Ma, Tiantian lyricists_name: Man, Keng lyricists_name: Wei, Li lyricists_name: Wong, Ian lyricists_id: AAALS99 lyricists_id: RBRAU10 lyricists_id: RJMWH01 lyricists_id: CYLAU57 lyricists_id: TTMAX05 lyricists_id: KCKMA73 lyricists_id: LWEIX32 lyricists_id: ICKWO00 actors_name: Lau, Cheuk Yin actors_id: CYLAU57 actors_role: owner full_text_status: public publication: Journal of Alzheimer's Disease event_location: Netherlands issn: 1387-2877 citation: Alsharif, AA; Wei, L; Ma, T; Man, KKC; Lau, WCY; Brauer, R; Almetwazi, M; ... Wong, ICK; + view all <#> Alsharif, AA; Wei, L; Ma, T; Man, KKC; Lau, WCY; Brauer, R; Almetwazi, M; Howard, R; Wong, ICK; - view fewer <#> (2020) Prevalence and Incidence of Dementia in People with Diabetes Mellitus. Journal of Alzheimer's Disease 10.3233/JAD-191115 <https://doi.org/10.3233/JAD-191115>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10095184/1/Manuscript%2019-1115R1_.pdf