eprintid: 10095184
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/09/51/84
datestamp: 2020-04-23 17:12:17
lastmod: 2021-09-18 21:52:19
status_changed: 2020-04-23 17:12:17
type: article
metadata_visibility: show
creators_name: Alsharif, AA
creators_name: Wei, L
creators_name: Ma, T
creators_name: Man, KKC
creators_name: Lau, WCY
creators_name: Brauer, R
creators_name: Almetwazi, M
creators_name: Howard, R
creators_name: Wong, ICK
title: Prevalence and Incidence of Dementia in People with Diabetes Mellitus
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
divisions: C08
divisions: D10
divisions: G11
keywords: Dementia, THIN database, diabetes mellitus, epidemiology, incidence, prevalence
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: BACKGROUND: Few studies have shown that an increased risk of dementia is associated with diabetes mellitus. OBJECTIVE: To estimate the prevalence and incidence of dementia in people with diabetes in primary care in the UK. 

METHODS: We conducted a descriptive study using the UK The Health Improvement Network (THIN) database. People diagnosed with diabetes from 2000 to 2016 were included in the study. Prevalence and incidence rates of dementia were calculated annually, stratified by age and gender. 

RESULTS: The prevalence of dementia was 0.424% [95% CI (0.420%-0.427%)] in 2000 and 2.508% [95% CI (2.501%-2.515%)] in 2016. The highest prevalence was in those aged 85+ from 2.9% [95% CI (2.890%-2.974%)] in 2000 to 11.3% [95% CI (11.285%-11.384%)] in 2016. The incidence of dementia increased 3.7 times, from 0.181 cases per 100 persons [95% CI (0.179-0.183)] in 2000 to 0.683 cases per 100 persons [95% CI (0.679-0.686)] in 2016, respectively. Women had a higher prevalence and incidence of dementia than men 3.138% [95% CI (3.127%-3.150%)] versus 2.014% [95% CI (2.006%-2.022%)] and 0.820 [95% CI (0.814-0.826)] versus 0.576 cases per 100 persons [95% CI (0.571-0.580)] in 2016, respectively. CONCLUSION: There was a trend of increasing prevalence and incidence of dementia in people with diabetes over the period of 2000 to 2016. This study adds to the evidence on dementia prevalence and incidence, particularly in the diabetic population.
date: 2020-04-13
date_type: published
official_url: https://doi.org/10.3233/JAD-191115
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1777075
doi: 10.3233/JAD-191115
pii: JAD191115
lyricists_name: Alsharif, Alaa
lyricists_name: Brauer, Ruth
lyricists_name: Howard, Robert
lyricists_name: Lau, Cheuk Yin
lyricists_name: Ma, Tiantian
lyricists_name: Man, Keng
lyricists_name: Wei, Li
lyricists_name: Wong, Ian
lyricists_id: AAALS99
lyricists_id: RBRAU10
lyricists_id: RJMWH01
lyricists_id: CYLAU57
lyricists_id: TTMAX05
lyricists_id: KCKMA73
lyricists_id: LWEIX32
lyricists_id: ICKWO00
actors_name: Lau, Cheuk Yin
actors_id: CYLAU57
actors_role: owner
full_text_status: public
publication: Journal of Alzheimer's Disease
event_location: Netherlands
issn: 1387-2877
citation:        Alsharif, AA;    Wei, L;    Ma, T;    Man, KKC;    Lau, WCY;    Brauer, R;    Almetwazi, M;         ... Wong, ICK; + view all <#>        Alsharif, AA;  Wei, L;  Ma, T;  Man, KKC;  Lau, WCY;  Brauer, R;  Almetwazi, M;  Howard, R;  Wong, ICK;   - view fewer <#>    (2020)    Prevalence and Incidence of Dementia in People with Diabetes Mellitus.                   Journal of Alzheimer's Disease        10.3233/JAD-191115 <https://doi.org/10.3233/JAD-191115>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10095184/1/Manuscript%2019-1115R1_.pdf