TY  - JOUR
UR  - https://doi.org/10.3233/JAD-191115
Y1  - 2020/04/13/
ID  - discovery10095184
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
TI  - Prevalence and Incidence of Dementia in People with Diabetes Mellitus
JF  - Journal of Alzheimer's Disease
KW  - Dementia
KW  -  THIN database
KW  -  diabetes mellitus
KW  -  epidemiology
KW  -  incidence
KW  -  prevalence
N2  - BACKGROUND: Few studies have shown that an increased risk of dementia is associated with diabetes mellitus. OBJECTIVE: To estimate the prevalence and incidence of dementia in people with diabetes in primary care in the UK. 

METHODS: We conducted a descriptive study using the UK The Health Improvement Network (THIN) database. People diagnosed with diabetes from 2000 to 2016 were included in the study. Prevalence and incidence rates of dementia were calculated annually, stratified by age and gender. 

RESULTS: The prevalence of dementia was 0.424% [95% CI (0.420%-0.427%)] in 2000 and 2.508% [95% CI (2.501%-2.515%)] in 2016. The highest prevalence was in those aged 85+ from 2.9% [95% CI (2.890%-2.974%)] in 2000 to 11.3% [95% CI (11.285%-11.384%)] in 2016. The incidence of dementia increased 3.7 times, from 0.181 cases per 100 persons [95% CI (0.179-0.183)] in 2000 to 0.683 cases per 100 persons [95% CI (0.679-0.686)] in 2016, respectively. Women had a higher prevalence and incidence of dementia than men 3.138% [95% CI (3.127%-3.150%)] versus 2.014% [95% CI (2.006%-2.022%)] and 0.820 [95% CI (0.814-0.826)] versus 0.576 cases per 100 persons [95% CI (0.571-0.580)] in 2016, respectively. CONCLUSION: There was a trend of increasing prevalence and incidence of dementia in people with diabetes over the period of 2000 to 2016. This study adds to the evidence on dementia prevalence and incidence, particularly in the diabetic population.
SN  - 1387-2877
A1  - Alsharif, AA
A1  - Wei, L
A1  - Ma, T
A1  - Man, KKC
A1  - Lau, WCY
A1  - Brauer, R
A1  - Almetwazi, M
A1  - Howard, R
A1  - Wong, ICK
AV  - public
ER  -