<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10094889> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/title> "Artificially decreasing cortical tension generates aneuploidy in mouse oocytes"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/abstract> "Human and mouse oocytes’ developmental potential can be predicted by their mechanical\r\nproperties. Their development into blastocysts requires a specific stiffness window. In this\r\nstudy, we combine live-cell and computational imaging, laser ablation, and biophysical\r\nmeasurements to investigate how deregulation of cortex tension in the oocyte contributes to\r\nearly developmental failure. We focus on extra-soft cells, the most common defect in a\r\nnatural population. Using two independent tools to artificially decrease cortical tension, we\r\nshow that chromosome alignment is impaired in extra-soft mouse oocytes, despite normal\r\nspindle morphogenesis and dynamics, inducing aneuploidy. The main cause is a cytoplasmic\r\nincrease in myosin-II activity that could sterically hinder chromosome capture. We describe\r\nhere an original mode of generation of aneuploidies that could be very common in oocytes\r\nand could contribute to the high aneuploidy rate observed during female meiosis, a leading\r\ncause of infertility and congenital disorders."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/date> "2020-04-03" .
<https://discovery.ucl.ac.uk/id/document/1081247> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/volume> "11" .
<https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://xmlns.com/foaf/0.1/name> "Nature Communications"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-351fa1bce2c1a2a289d71e7716f70b35> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-351fa1bce2c1a2a289d71e7716f70b35> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ad75da7f547fd30b3d0b522ee017b56e> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-ad75da7f547fd30b3d0b522ee017b56e> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-21f50ce21760fa43e332599f17f71519> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-21f50ce21760fa43e332599f17f71519> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0c1429a37561ee63bcd01793084c40c8> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-0c1429a37561ee63bcd01793084c40c8> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2e039d7c6baf61460938021b5adef414> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-2e039d7c6baf61460938021b5adef414> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fb0e39ab6b06fb9754d900e10ad6c274> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-fb0e39ab6b06fb9754d900e10ad6c274> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-039507a146dafef22b67d39d9e7f91b1> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-039507a146dafef22b67d39d9e7f91b1> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-98b9b6088a4afe4045f1d928660a3f28> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-98b9b6088a4afe4045f1d928660a3f28> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6362bdff72824ef55861a7d10bf901ca> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-6362bdff72824ef55861a7d10bf901ca> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0e90497195ad4ec0d7d1941c6ad97991> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-0e90497195ad4ec0d7d1941c6ad97991> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e96507f446fa2f2dd90412672e89257d> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-e96507f446fa2f2dd90412672e89257d> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-db496d9cd71b118bb0fcb4b8e5ccf697> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-db496d9cd71b118bb0fcb4b8e5ccf697> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2c2e2f47325dc1b12e1e5d400b59e459> .
<https://discovery.ucl.ac.uk/id/eprint/10094889> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10094889#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10094889#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-2c2e2f47325dc1b12e1e5d400b59e459> .
<https://discovery.ucl.ac.uk/id/person/ext-0c1429a37561ee63bcd01793084c40c8> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0c1429a37561ee63bcd01793084c40c8> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0c1429a37561ee63bcd01793084c40c8> <http://xmlns.com/foaf/0.1/familyName> "Chaigne"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0c1429a37561ee63bcd01793084c40c8> <http://xmlns.com/foaf/0.1/name> "A Chaigne"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db496d9cd71b118bb0fcb4b8e5ccf697> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-db496d9cd71b118bb0fcb4b8e5ccf697> <http://xmlns.com/foaf/0.1/givenName> "M-H"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db496d9cd71b118bb0fcb4b8e5ccf697> <http://xmlns.com/foaf/0.1/familyName> "Verlhac"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-db496d9cd71b118bb0fcb4b8e5ccf697> <http://xmlns.com/foaf/0.1/name> "M-H Verlhac"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-21f50ce21760fa43e332599f17f71519> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-21f50ce21760fa43e332599f17f71519> <http://xmlns.com/foaf/0.1/givenName> "E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-21f50ce21760fa43e332599f17f71519> <http://xmlns.com/foaf/0.1/familyName> "Nikalayevich"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-21f50ce21760fa43e332599f17f71519> <http://xmlns.com/foaf/0.1/name> "E Nikalayevich"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ad75da7f547fd30b3d0b522ee017b56e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ad75da7f547fd30b3d0b522ee017b56e> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ad75da7f547fd30b3d0b522ee017b56e> <http://xmlns.com/foaf/0.1/familyName> "Crozet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ad75da7f547fd30b3d0b522ee017b56e> <http://xmlns.com/foaf/0.1/name> "F Crozet"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-039507a146dafef22b67d39d9e7f91b1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-039507a146dafef22b67d39d9e7f91b1> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-039507a146dafef22b67d39d9e7f91b1> <http://xmlns.com/foaf/0.1/familyName> "Campillo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-039507a146dafef22b67d39d9e7f91b1> <http://xmlns.com/foaf/0.1/name> "C Campillo"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb0e39ab6b06fb9754d900e10ad6c274> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fb0e39ab6b06fb9754d900e10ad6c274> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb0e39ab6b06fb9754d900e10ad6c274> <http://xmlns.com/foaf/0.1/familyName> "Manil-Ségalen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fb0e39ab6b06fb9754d900e10ad6c274> <http://xmlns.com/foaf/0.1/name> "M Manil-Ségalen"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-351fa1bce2c1a2a289d71e7716f70b35> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-351fa1bce2c1a2a289d71e7716f70b35> <http://xmlns.com/foaf/0.1/givenName> "I"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-351fa1bce2c1a2a289d71e7716f70b35> <http://xmlns.com/foaf/0.1/familyName> "Bennabi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-351fa1bce2c1a2a289d71e7716f70b35> <http://xmlns.com/foaf/0.1/name> "I Bennabi"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e039d7c6baf61460938021b5adef414> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2e039d7c6baf61460938021b5adef414> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e039d7c6baf61460938021b5adef414> <http://xmlns.com/foaf/0.1/familyName> "Letort"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2e039d7c6baf61460938021b5adef414> <http://xmlns.com/foaf/0.1/name> "G Letort"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2c2e2f47325dc1b12e1e5d400b59e459> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2c2e2f47325dc1b12e1e5d400b59e459> <http://xmlns.com/foaf/0.1/givenName> "M-E"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2c2e2f47325dc1b12e1e5d400b59e459> <http://xmlns.com/foaf/0.1/familyName> "Terret"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2c2e2f47325dc1b12e1e5d400b59e459> <http://xmlns.com/foaf/0.1/name> "M-E Terret"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0e90497195ad4ec0d7d1941c6ad97991> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0e90497195ad4ec0d7d1941c6ad97991> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0e90497195ad4ec0d7d1941c6ad97991> <http://xmlns.com/foaf/0.1/familyName> "Attia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0e90497195ad4ec0d7d1941c6ad97991> <http://xmlns.com/foaf/0.1/name> "R Attia"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e96507f446fa2f2dd90412672e89257d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e96507f446fa2f2dd90412672e89257d> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e96507f446fa2f2dd90412672e89257d> <http://xmlns.com/foaf/0.1/familyName> "Genovesio"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e96507f446fa2f2dd90412672e89257d> <http://xmlns.com/foaf/0.1/name> "A Genovesio"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6362bdff72824ef55861a7d10bf901ca> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6362bdff72824ef55861a7d10bf901ca> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6362bdff72824ef55861a7d10bf901ca> <http://xmlns.com/foaf/0.1/familyName> "Othmani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6362bdff72824ef55861a7d10bf901ca> <http://xmlns.com/foaf/0.1/name> "A Othmani"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-98b9b6088a4afe4045f1d928660a3f28> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-98b9b6088a4afe4045f1d928660a3f28> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-98b9b6088a4afe4045f1d928660a3f28> <http://xmlns.com/foaf/0.1/familyName> "Cadart"^^<http://www.w3.org/2001/XMLSchema#string> .
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