eprintid: 10094819
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/09/48/19
datestamp: 2020-04-27 11:00:27
lastmod: 2021-12-30 23:24:33
status_changed: 2020-04-27 11:00:27
type: article
metadata_visibility: show
creators_name: Iliopoulos, F
creators_name: Monjur Al Hossain, ASM
creators_name: Sil, BC
creators_name: Moore, DJ
creators_name: Lucas, RA
creators_name: Lane, ME
title: Topical delivery of 3-O-ethyl L-ascorbic acid from complex solvent systems
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: in vitro; topical formulations; porcine skin permeation; cosmetic and pharmaceutical product technology; finite dose; 3-O-ethyl l-ascorbic acid; antioxidant; vitamin C
note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: 3-O-ethyl l-ascorbic acid (EA), an ether derivative of Vitamin C, is widely used in skincare formulations. Previously, we reported the effects of neat solvents on EA percutaneous absorption and observed that 0.6–7.5% of the applied EA was delivered through the skin over 24 h. In this work, we designed complex formulations using combinations of solvents that may act synergistically and examined their impact on EA permeation in porcine skin in vitro under finite dose conditions. Binary combinations of propylene glycol (PG) with propylene glycol monolaurate (PGML) were effective in enhancing skin permeation of EA compared with individual solvents (p < 0.05). Combining PGML with 1,2-hexanediol (HEX) did not result in significantly higher EA permeation compared with the neat solvents (p > 0.05). Addition of the volatile solvent isopropyl alcohol (IPA) to PG solutions also did not improve EA skin delivery compared with neat PG. Ternary solvent systems containing PG:PGML were subsequently prepared by the addition of a lipophilic solvent, either isopropyl myristate (IPM), medium-chain triglycerides (MCT) or isostearyl isostearate (ISIS). The optimum vehicle, PG:PGML:IPM, promoted up to 70.9% skin delivery of EA. The PG:PGML:ISIS vehicles also promoted EA permeation across the skin, but to a significantly lesser extent than the IPM-containing vehicles. No enhancement of EA delivery was noted for the PG:PGML:MCT mixtures. These results will inform the development of targeted formulations for EA in the future.
date: 2020
date_type: published
official_url: https://doi.org/10.3390/scipharm88020019
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1775902
doi: 10.3390/scipharm88020019
lyricists_name: Iliopoulos, Fotis
lyricists_name: Lane, Majella
lyricists_id: FILIO03
lyricists_id: MLANE69
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Scientia Pharmaceutica
volume: 88
number: 2
article_number: 19
issn: 2218-0532
citation:        Iliopoulos, F;    Monjur Al Hossain, ASM;    Sil, BC;    Moore, DJ;    Lucas, RA;    Lane, ME;      (2020)    Topical delivery of 3-O-ethyl L-ascorbic acid from complex solvent systems.                   Scientia Pharmaceutica , 88  (2)    , Article 19.  10.3390/scipharm88020019 <https://doi.org/10.3390/scipharm88020019>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10094819/11/scipharm-88-00019-v3.pdf