eprintid: 10094593
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/09/45/93
datestamp: 2020-04-08 13:22:23
lastmod: 2021-10-04 00:31:18
status_changed: 2020-04-08 13:22:23
type: article
metadata_visibility: show
creators_name: Dregan, A
creators_name: McNeill, A
creators_name: Gaughran, F
creators_name: Jones, PB
creators_name: Bazley, A
creators_name: Cross, S
creators_name: Lillywhite, K
creators_name: Armstrong, D
creators_name: Smith, S
creators_name: Osborn, DPJ
creators_name: Stewart, R
creators_name: Wykes, T
creators_name: Hotopf, M
title: Potential gains in life expectancy from reducing amenable mortality among people diagnosed with serious mental illness in the United Kingdom
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
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abstract: BACKGROUND: To estimate the potential gain in life expectancy from addressing modifiable risk factors for all-cause mortality (excluding suicide and deaths from accidents or violence) across specific serious mental illness (SMI) subgroups, namely schizophrenia, schizoaffective disorders, and bipolar disorders in a Western population. METHODS: We have used relative risks from recent meta-analyses to estimate the population attribution fraction (PAF) due to specific modifiable risk factors known to be associated with all-cause mortality within SMI. The potential gain in life expectancy at birth, age 50 and age 65 years were assessed by estimating the combined effect of modifiable risk factors from different contextual levels (behavioural, healthcare, social) and accounting for the effectiveness of existing interventions tackling these factors. Projections for annual gain in life expectancy at birth during a two-decade was estimated using the Annual Percentage Change (APC) formula. The predicted estimates were based on mortality rates for year 2014-2015. RESULTS: Based on the effectiveness of existing interventions targeting these modifiable risk factors, we estimated potential gain in life expectancy at birth of four (bipolar disorders), six (schizoaffective disorders), or seven years (schizophrenia). The gain in life expectancy at age 50 years was three (bipolar disorders) or five (schizophrenia and schizoaffective disorders) years. The projected gain in life expectancy at age 65 years was three (bipolar disorders) or four (schizophrenia and schizoaffective disorders) years. CONCLUSIONS: The implementation of existing interventions targeting modifiable risk factors could narrow the current mortality gap between the general and the SMI populations by 24% (men) to 28% (women). These projections represent ideal circumstances and without the limitation of overestimation which often comes with PAFs.
date: 2020-03-27
date_type: published
official_url: https://doi.org/10.1371/journal.pone.0230674
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1774980
doi: 10.1371/journal.pone.0230674
pii: PONE-D-19-27607
lyricists_name: Osborn, David
lyricists_id: DPJOS02
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: PLOS ONE
volume: 15
number: 3
article_number: e0230674
event_location: United States
citation:        Dregan, A;    McNeill, A;    Gaughran, F;    Jones, PB;    Bazley, A;    Cross, S;    Lillywhite, K;                         ... Hotopf, M; + view all <#>        Dregan, A;  McNeill, A;  Gaughran, F;  Jones, PB;  Bazley, A;  Cross, S;  Lillywhite, K;  Armstrong, D;  Smith, S;  Osborn, DPJ;  Stewart, R;  Wykes, T;  Hotopf, M;   - view fewer <#>    (2020)    Potential gains in life expectancy from reducing amenable mortality among people diagnosed with serious mental illness in the United Kingdom.                   PLOS ONE , 15  (3)    , Article e0230674.  10.1371/journal.pone.0230674 <https://doi.org/10.1371/journal.pone.0230674>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10094593/1/journal.pone.0230674.pdf