eprintid: 10094446
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/09/44/46
datestamp: 2020-04-07 11:38:07
lastmod: 2021-10-18 00:31:45
status_changed: 2020-04-07 11:38:07
type: article
metadata_visibility: show
creators_name: Hamel, W
creators_name: Koeppen, JA
creators_name: Alesch, F
creators_name: Antonini, A
creators_name: Barcia, JA
creators_name: Bergman, H
creators_name: Chabardes, S
creators_name: Contarino, MF
creators_name: Cornu, P
creators_name: Demmel, W
creators_name: Deuschl, G
creators_name: Fasano, A
creators_name: Kuehn, AA
creators_name: Limousin, P
creators_name: McIntyre, CC
creators_name: Mehdorn, HM
creators_name: Pilleri, M
creators_name: Pollak, P
creators_name: Rodriguez-Oroz, MC
creators_name: Rumia, J
creators_name: Samuel, M
creators_name: Timmermann, L
creators_name: Valldeoriola, F
creators_name: Vesper, J
creators_name: Visser-Vandewalle, V
creators_name: Volkmann, J
creators_name: Lozano, AM
title: Targeting of the Subthalamic Nucleus for Deep Brain Stimulation: A Survey Among Parkinson Disease Specialists
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Deep brain stimulation, Parkinson disease, Subthalamic nucleus, Targeting
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher's terms and conditions.
abstract: BACKGROUND:  Deep brain stimulation within or adjacent to the subthalamic nucleus (STN) represents the most common stereotactic procedure performed for Parkinson disease. Better STN imaging is often regarded as a requirement for improving stereotactic targeting. However, it is unclear whether there is consensus about the optimal target. METHODS: To obtain an expert opinion on the site regarded optimal for “STN stimulation,” movement disorder specialists were asked to indicate their preferred position for an active contact on hard copies of the Schaltenbrand and Wahren atlas depicting the STN in all 3 planes. This represented an idealized setting, and it mimicked optimal imaging for direct target definition in a perfectly delineated STN. RESULTS: The suggested targets were heterogeneous, although some clustering was observed in the dorsolateral STN and subthalamic area. In particular, in the anteroposterior direction, the intended targets differed to a great extent. Most of the indicated targets are thought to also result in concomitant stimulation of structures adjacent to the STN, including the zona incerta, fields of Forel, and internal capsule. CONCLUSIONS: This survey illustrates that most sites regarded as optimal for STN stimulation are close to each other, but there appears to be no uniform perception of the optimal anatomic target, possibly influencing surgical results. The anatomic sweet zone for STN stimulation needs further specification, as this information is likely to make magnetic resonance imaging–based target definition less variable when applied to individual patients.
date: 2017-03
date_type: published
publisher: ELSEVIER SCIENCE INC
official_url: https://doi.org/10.1016/j.wneu.2016.11.012
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1191798
doi: 10.1016/j.wneu.2016.11.012
lyricists_name: Limousin, Patricia
lyricists_id: PDLIM44
actors_name: Limousin, Patricia
actors_name: Taib, Linda
actors_id: PDLIM44
actors_id: LTAIB41
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: World Neurosurgery
volume: 99
pagerange: 41-46
pages: 6
issn: 1878-8750
citation:        Hamel, W;    Koeppen, JA;    Alesch, F;    Antonini, A;    Barcia, JA;    Bergman, H;    Chabardes, S;                                                                                 ... Lozano, AM; + view all <#>        Hamel, W;  Koeppen, JA;  Alesch, F;  Antonini, A;  Barcia, JA;  Bergman, H;  Chabardes, S;  Contarino, MF;  Cornu, P;  Demmel, W;  Deuschl, G;  Fasano, A;  Kuehn, AA;  Limousin, P;  McIntyre, CC;  Mehdorn, HM;  Pilleri, M;  Pollak, P;  Rodriguez-Oroz, MC;  Rumia, J;  Samuel, M;  Timmermann, L;  Valldeoriola, F;  Vesper, J;  Visser-Vandewalle, V;  Volkmann, J;  Lozano, AM;   - view fewer <#>    (2017)    Targeting of the Subthalamic Nucleus for Deep Brain Stimulation: A Survey Among Parkinson Disease Specialists.                   World Neurosurgery , 99    pp. 41-46.    10.1016/j.wneu.2016.11.012 <https://doi.org/10.1016/j.wneu.2016.11.012>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10094446/1/WNS-16-1481R1_Survey_revision.pdf