eprintid: 10093958 rev_number: 24 eprint_status: archive userid: 608 dir: disk0/10/09/39/58 datestamp: 2020-03-25 16:43:32 lastmod: 2021-09-24 22:08:19 status_changed: 2020-08-13 16:21:18 type: article metadata_visibility: show creators_name: Binetti, N creators_name: Tomassini, A creators_name: Friston, K creators_name: Bestmann, S title: Uncoupling Sensation and Perception in Human Time Processing ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 divisions: F83 note: Copyright © 2020 Massachusetts Institute of Technology. Published under a Creative Commons Attribution 4.0 International (CC BY 4.0) license. abstract: Timing emerges from a hierarchy of computations ranging from early encoding of physical duration (time sensation) to abstract time representations (time perception) suitable for storage and decisional processes.However, the neural basis of the perceptual experience of time remains elusive. To address this, we dissociate brain activity uniquely related to lower-level sensory and higher-order perceptual timing operations, using eventrelated fMRI. Participants compared subsecond (500 msec) sinusoidal gratings drifting with constant velocity (standard) against two probe stimuli: (1) control gratings drifting at constant velocity or (2) accelerating gratings, which induced illusory shortening of time. We tested two probe intervals: a 500-msec duration (Short) and a longer duration required for an accelerating probe to be perceived as long as the standard (Long—individually determined). On each trial, participants classified the probe as shorter or longer than the standard. This allowed for comparison of trials with an “Objective” (physical) or “Subjective” (perceived) difference in duration, based on participant classifications. Objective duration revealed responses in bilateral early extrastriate areas, extending to higher visual areas in the fusiform gyrus (at more lenient thresholds). By contrast, Subjective duration was reflected by distributed responses in a cortical/subcortical areas. This comprised the left superior frontal gyrus and the left cerebellum, and a wider set of common timing areas including the BG, parietal cortex, and posterior cingulate cortex. These results suggest two functionally independent timing stages: early extraction of duration information in sensory cortices and Subjective experience of duration in a higher-order cortical–subcortical timing areas. date: 2020-07 date_type: published official_url: https://doi.org/10.1162/jocn_a_01557 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1773450 doi: 10.1162/jocn_a_01557 lyricists_name: Bestmann, Sven lyricists_name: Friston, Karl lyricists_id: SBEST86 lyricists_id: KJFRI52 actors_name: Flynn, Bernadette actors_id: BFFLY94 actors_role: owner full_text_status: public publication: Journal of Cognitive Neuroscience volume: 32 number: 7 pagerange: 1369-1380 event_location: United States citation: Binetti, N; Tomassini, A; Friston, K; Bestmann, S; (2020) Uncoupling Sensation and Perception in Human Time Processing. Journal of Cognitive Neuroscience , 32 (7) pp. 1369-1380. 10.1162/jocn_a_01557 <https://doi.org/10.1162/jocn_a_01557>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10093958/7/Bestmann_jocn_a_01557.pdf