eprintid: 10093484
rev_number: 21
eprint_status: archive
userid: 608
dir: disk0/10/09/34/84
datestamp: 2020-03-23 16:27:16
lastmod: 2021-09-20 22:26:58
status_changed: 2020-03-23 16:27:16
type: article
metadata_visibility: show
creators_name: Wang, H
creators_name: Williams, GR
creators_name: Xie, X
creators_name: Wu, M
creators_name: Wu, J
creators_name: Zhu, L-M
title: Stealth Polydopamine-Based Nanoparticles with Red Blood Cell Membrane for the Chemo-Photothermal Therapy of Cancer
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G08
keywords: red blood cell membrane, biomimetic, polydopamine, curcumin, chemo-photothermal therapy
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Herein, we developed curcumin (Cur)-loaded porous poly(lactic-co-glycolic acid) (pPLGA) nanoparticles (NPs) by the nanoprecipitation method. Dopamine (DA) was then self-polymerized to form a polydopamine (PDA) layer on the surface of the NPs, yielding Cur@pPLGA/PDA NPs that are able to act as both chemotherapeutic and photothermal agents. These NPs were further camouflaged with the red blood cell membrane (RBCM) to construct RBCM-Cur@pPLGA/PDA NPs. The RBCM-pPLGA/PDA NPs were around 200 nm in size and demonstrated photothermal performance in the near-infrared (NIR) region, with a potent conversion efficiency (35.2%). The blank carrier has favorable cytocompatibility, but when drug loaded the NPs can efficiently induce the death of cancer cells (particularly when combined with NIR laser treatment). Cellular uptake results revealed greater in vitro uptake of RBCM-Cur@pPLGA/PDA NPs than bare Cur@pPLGA/PDA NPs in the case of cancer cells but reduced macrophage phagocytosis. In vivo studies in mice showed that the RBCM-Cur@pPLGA/PDA NPs exhibited prolonged blood circulation times and excellent photothermal properties, allowing tumor-specific chemo-photothermal therapy. The RBCM-Cur@pPLGA/PDA NP platform presents great potential for targeted synergistic cancer treatments.
date: 2020-04-20
publisher: American Chemical Society (ACS)
official_url: https://doi.org/10.1021/acsabm.0c00094
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1772113
doi: 10.1021/acsabm.0c00094
lyricists_name: Williams, Gareth
lyricists_id: GWILL02
actors_name: Williams, Gareth
actors_id: GWILL02
actors_role: owner
full_text_status: public
publication: ACS Applied Bio Materials
volume: 3
number: 4
pagerange: 2350-2359
citation:        Wang, H;    Williams, GR;    Xie, X;    Wu, M;    Wu, J;    Zhu, L-M;      (2020)    Stealth Polydopamine-Based Nanoparticles with Red Blood Cell Membrane for the Chemo-Photothermal Therapy of Cancer.                   ACS Applied Bio Materials , 3  (4)   pp. 2350-2359.    10.1021/acsabm.0c00094 <https://doi.org/10.1021/acsabm.0c00094>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10093484/1/acsabm.0c00094.pdf