eprintid: 10093020 rev_number: 14 eprint_status: archive userid: 608 dir: disk0/10/09/30/20 datestamp: 2020-03-10 15:48:08 lastmod: 2021-09-17 22:29:44 status_changed: 2020-03-10 15:48:08 type: article metadata_visibility: show creators_name: Visser, JC creators_name: Wibier, L creators_name: Kiefer, O creators_name: Orlu, M creators_name: Breitkreutz, J creators_name: Woerdenbag, HJ creators_name: Taxis, K title: A Pediatrics Utilization Study in The Netherlands to Identify Active Pharmaceutical Ingredients Suitable for Inkjet Printing on Orodispersible Films ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D10 divisions: G08 keywords: drug utilization research, orodispersible films, pediatrics, pharmaceutical inkjet printing, pharmacy note: Background: The use of medication in pediatrics, children aged 0–5 years, was explored so as to identify active pharmaceutical ingredients (APIs) suitable for inkjet printing on a plain orodispersible film (ODF) formulation in a pharmacy. Methods: The database IADB.nl, containing pharmacy dispensing data from community pharmacies in the Netherlands, was used to explore medication use in the age group of 0–5 years old, based on the Anatomical Therapeutic Chemical classification code (ATC code). Subsequently, a stepwise approach with four exclusion steps was used to identify the drug candidates for ODF formulation development. Results: there were 612 Active Pharmaceutical Ingredients (APIs) that were dispensed to the target group, mostly antibiotics. Of the APIs, 221 were not registered for pediatrics, but were used off-label. After the exclusion steps, 34 APIs were examined regarding their suitability for inkjet printing. Almost all of the APIs were sparingly water soluble to practically insoluble. Conclusion: Pharmaceutical inkjet printing is a suitable new technique for ODF manufacturing for pediatric application, however the maximal printed dose as found in the literature remained low. From the selected candidates, only montelukast shows a sufficiently high water-solubility to prepare a water-based solution. To achieve higher drug loads per ODF is ambitious, but is theoretically possible by printing multiple layers, using highly water-soluble APIs or highly loaded suspensions. abstract: Background: The use of medication in pediatrics, children aged 0–5 years, was explored so as to identify active pharmaceutical ingredients (APIs) suitable for inkjet printing on a plain orodispersible film (ODF) formulation in a pharmacy. Methods: The database IADB.nl, containing pharmacy dispensing data from community pharmacies in the Netherlands, was used to explore medication use in the age group of 0–5 years old, based on the Anatomical Therapeutic Chemical classification code (ATC code). Subsequently, a stepwise approach with four exclusion steps was used to identify the drug candidates for ODF formulation development. Results: there were 612 Active Pharmaceutical Ingredients (APIs) that were dispensed to the target group, mostly antibiotics. Of the APIs, 221 were not registered for pediatrics, but were used off-label. After the exclusion steps, 34 APIs were examined regarding their suitability for inkjet printing. Almost all of the APIs were sparingly water soluble to practically insoluble. Conclusion: Pharmaceutical inkjet printing is a suitable new technique for ODF manufacturing for pediatric application, however the maximal printed dose as found in the literature remained low. From the selected candidates, only montelukast shows a sufficiently high water-solubility to prepare a water-based solution. To achieve higher drug loads per ODF is ambitious, but is theoretically possible by printing multiple layers, using highly water-soluble APIs or highly loaded suspensions. date: 2020-02-17 date_type: published official_url: https://doi.org/10.3390/pharmaceutics12020164 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1769929 doi: 10.3390/pharmaceutics12020164 pii: pharmaceutics12020164 language_elements: eng lyricists_name: Orlu, Mine lyricists_id: MORLU15 actors_name: Orlu, Mine actors_name: Harris, Jean actors_id: MORLU15 actors_id: JAHAR68 actors_role: owner actors_role: impersonator full_text_status: public publication: Pharmaceutics volume: 12 number: 2 article_number: 164 event_location: Switzerland citation: Visser, JC; Wibier, L; Kiefer, O; Orlu, M; Breitkreutz, J; Woerdenbag, HJ; Taxis, K; (2020) A Pediatrics Utilization Study in The Netherlands to Identify Active Pharmaceutical Ingredients Suitable for Inkjet Printing on Orodispersible Films. Pharmaceutics , 12 (2) , Article 164. 10.3390/pharmaceutics12020164 <https://doi.org/10.3390/pharmaceutics12020164>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10093020/1/pharmaceutics-12-00164.pdf