<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10092638> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/title> "Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/abstract> "Genetic and environmental factors are key drivers regulating organismal lifespan but how these impact healthspan is less well understood. Techniques capturing biomechanical properties of tissues on a nano-scale level are providing new insights into disease mechanisms. Here, we apply Atomic Force Microscopy (AFM) to quantitatively measure the change in biomechanical properties associated with ageing Caenorhabditis elegans in addition to capturing high-resolution topographical images of cuticle senescence. We show that distinct dietary restriction regimes and genetic pathways that increase lifespan lead to radically different healthspan outcomes. Hence, our data support the view that prolonged lifespan does not always coincide with extended healthspan. Importantly, we identify the insulin signalling pathway in C. elegans and interventions altering bacterial physiology as increasing both lifespan and healthspan. Overall, AFM provides a highly sensitive technique to measure organismal biomechanical fitness and delivers an approach to screen for health-improving conditions, an essential step towards healthy ageing."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/date> "2020-02-25" .
<https://discovery.ucl.ac.uk/id/document/1062012> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/volume> "11" .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/issue> "1" .
<https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> <http://xmlns.com/foaf/0.1/name> "Nature Communications"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-93ad60708ded9f1ac36bc6a921129f1f> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
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<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-842c183a76e9a30057710445eb977fb4> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-8bc4f3888cf1d0eaf58654004601ec07> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-8bc4f3888cf1d0eaf58654004601ec07> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c765173f6d198534cd3571483cf3b8bd> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-c765173f6d198534cd3571483cf3b8bd> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-9953e99469524582a9cb57f75a275c7e> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-9953e99469524582a9cb57f75a275c7e> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-fa350bdf3ba980ff14e908b1c8b21807> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-fa350bdf3ba980ff14e908b1c8b21807> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-ba7da104de1fbf15e5ca9197cab5243a> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-ba7da104de1fbf15e5ca9197cab5243a> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-5e5fbd91395e8ae9416dbae3d8058cf0> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-5e5fbd91395e8ae9416dbae3d8058cf0> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e9791611502b238e5dd443b2aafbb24d> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-e9791611502b238e5dd443b2aafbb24d> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-dffd71a3c3cb68d9aac8f98f6b670766> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-dffd71a3c3cb68d9aac8f98f6b670766> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2deabd3fee715e1e83f7c83c1024b91d> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-2deabd3fee715e1e83f7c83c1024b91d> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0cb64c312645daf2e91dff4976fa9749> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10092638#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10092638#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-0cb64c312645daf2e91dff4976fa9749> .
<https://discovery.ucl.ac.uk/id/person/ext-0cb64c312645daf2e91dff4976fa9749> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-0cb64c312645daf2e91dff4976fa9749> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0cb64c312645daf2e91dff4976fa9749> <http://xmlns.com/foaf/0.1/familyName> "Cabreiro"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-0cb64c312645daf2e91dff4976fa9749> <http://xmlns.com/foaf/0.1/name> "F Cabreiro"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-842c183a76e9a30057710445eb977fb4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-842c183a76e9a30057710445eb977fb4> <http://xmlns.com/foaf/0.1/givenName> "CL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-842c183a76e9a30057710445eb977fb4> <http://xmlns.com/foaf/0.1/familyName> "Essmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-842c183a76e9a30057710445eb977fb4> <http://xmlns.com/foaf/0.1/name> "CL Essmann"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba7da104de1fbf15e5ca9197cab5243a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-ba7da104de1fbf15e5ca9197cab5243a> <http://xmlns.com/foaf/0.1/givenName> "PP"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba7da104de1fbf15e5ca9197cab5243a> <http://xmlns.com/foaf/0.1/familyName> "Lui"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-ba7da104de1fbf15e5ca9197cab5243a> <http://xmlns.com/foaf/0.1/name> "PP Lui"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dffd71a3c3cb68d9aac8f98f6b670766> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-dffd71a3c3cb68d9aac8f98f6b670766> <http://xmlns.com/foaf/0.1/givenName> "VM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dffd71a3c3cb68d9aac8f98f6b670766> <http://xmlns.com/foaf/0.1/familyName> "Pawar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-dffd71a3c3cb68d9aac8f98f6b670766> <http://xmlns.com/foaf/0.1/name> "VM Pawar"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9791611502b238e5dd443b2aafbb24d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e9791611502b238e5dd443b2aafbb24d> <http://xmlns.com/foaf/0.1/givenName> "AEX"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9791611502b238e5dd443b2aafbb24d> <http://xmlns.com/foaf/0.1/familyName> "Brown"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e9791611502b238e5dd443b2aafbb24d> <http://xmlns.com/foaf/0.1/name> "AEX Brown"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8bc4f3888cf1d0eaf58654004601ec07> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-8bc4f3888cf1d0eaf58654004601ec07> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8bc4f3888cf1d0eaf58654004601ec07> <http://xmlns.com/foaf/0.1/familyName> "Martinez-Martinez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-8bc4f3888cf1d0eaf58654004601ec07> <http://xmlns.com/foaf/0.1/name> "D Martinez-Martinez"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fa350bdf3ba980ff14e908b1c8b21807> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-fa350bdf3ba980ff14e908b1c8b21807> <http://xmlns.com/foaf/0.1/givenName> "KB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fa350bdf3ba980ff14e908b1c8b21807> <http://xmlns.com/foaf/0.1/familyName> "Krishnan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-fa350bdf3ba980ff14e908b1c8b21807> <http://xmlns.com/foaf/0.1/name> "KB Krishnan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2deabd3fee715e1e83f7c83c1024b91d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2deabd3fee715e1e83f7c83c1024b91d> <http://xmlns.com/foaf/0.1/givenName> "MA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2deabd3fee715e1e83f7c83c1024b91d> <http://xmlns.com/foaf/0.1/familyName> "Srinivasan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2deabd3fee715e1e83f7c83c1024b91d> <http://xmlns.com/foaf/0.1/name> "MA Srinivasan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5e5fbd91395e8ae9416dbae3d8058cf0> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-5e5fbd91395e8ae9416dbae3d8058cf0> <http://xmlns.com/foaf/0.1/givenName> "NDE"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5e5fbd91395e8ae9416dbae3d8058cf0> <http://xmlns.com/foaf/0.1/familyName> "Greene"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-5e5fbd91395e8ae9416dbae3d8058cf0> <http://xmlns.com/foaf/0.1/name> "NDE Greene"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c765173f6d198534cd3571483cf3b8bd> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c765173f6d198534cd3571483cf3b8bd> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c765173f6d198534cd3571483cf3b8bd> <http://xmlns.com/foaf/0.1/familyName> "Pryor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c765173f6d198534cd3571483cf3b8bd> <http://xmlns.com/foaf/0.1/name> "R Pryor"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9953e99469524582a9cb57f75a275c7e> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-9953e99469524582a9cb57f75a275c7e> <http://xmlns.com/foaf/0.1/givenName> "K-Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9953e99469524582a9cb57f75a275c7e> <http://xmlns.com/foaf/0.1/familyName> "Leung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-9953e99469524582a9cb57f75a275c7e> <http://xmlns.com/foaf/0.1/name> "K-Y Leung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1062012> .
<https://discovery.ucl.ac.uk/id/document/1062012> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1062012> <http://www.w3.org/2000/01/rdf-schema#label> "Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. elegans (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1062012> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1062012> .
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<https://discovery.ucl.ac.uk/id/eprint/10092638/1/s41467-020-14785-0.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "s41467-020-14785-0.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10092638> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1062014> .
<https://discovery.ucl.ac.uk/id/document/1062014> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
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