eprintid: 10092446
rev_number: 24
eprint_status: archive
userid: 608
dir: disk0/10/09/24/46
datestamp: 2021-10-18 13:53:19
lastmod: 2021-10-18 13:53:19
status_changed: 2021-10-18 13:53:19
type: working_paper
metadata_visibility: show
creators_name: Wee, RWS
creators_name: MacAskill, AF
title: Biased connectivity of brain-wide inputs to ventral subiculum output neurons
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: G02
note: The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
abstract: The ventral subiculum (vS) of the mouse hippocampus coordinates diverse behaviours through heterogeneous populations of projection neurons. These neurons transmit signals to multiple brain regions by integrating thousands of local and long-range synaptic inputs. However, whether each population is selectively innervated by different afferent input remains unknown. To address this question, we employed projection-specific rabies tracing to study the input-output relationship of vS output neurons. Analysis of brain-wide inputs reveals quantitative input differences that can be explained by the spatial location of postsynaptic neurons along the proximal-distal axis of vS and the identity of the downstream target. Further, the input from nucleus reuniens, an area thought to underlie vS and prefrontal cortex (PFC) reciprocal connectivity, is unexpectedly biased away from PFC-projecting vS neurons. Overall, we reveal prominent heterogeneity in brain-wide inputs to the vS parallel output circuitry, providing a basis for the selective control of individual projections during behaviour.
date: 2019-08-06
date_type: published
publisher: BioRxiv
official_url: https://doi.org/10.1101/726406
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1684440
doi: 10.1101/726406
lyricists_name: Macaskill, Andrew
lyricists_id: AFMAC80
actors_name: Allington-Smith, Dominic
actors_id: DAALL44
actors_role: owner
full_text_status: public
place_of_pub: Cold Spring Harbor, NY, USA
pages: 32
citation:        Wee, RWS;    MacAskill, AF;      (2019)    Biased connectivity of brain-wide inputs to ventral subiculum output neurons.                    BioRxiv: Cold Spring Harbor, NY, USA.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10092446/7/Macaskill_726406v1.full.pdf