eprintid: 10091801
rev_number: 14
eprint_status: archive
userid: 608
dir: disk0/10/09/18/01
datestamp: 2020-02-20 10:16:04
lastmod: 2021-11-18 23:18:38
status_changed: 2020-02-20 10:16:04
type: article
metadata_visibility: show
creators_name: Desfougères, Y
creators_name: Saiardi, A
creators_name: Azevedo, C
title: Inorganic polyphosphate in mammals: where's Wally?
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D77
keywords: Cell metabolism, inorganic polyphosphates, phosphate, post translational modification, signalling
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abstract: Inorganic polyphosphate (polyP) is a ubiquitous polymer of tens to hundreds of orthophosphate residues linked by high-energy phosphoanhydride bonds. In prokaryotes and lower eukaryotes, both the presence of polyP and of the biosynthetic pathway that leads to its synthesis are well-documented. However, in mammals, polyP is more elusive. Firstly, the mammalian enzyme responsible for the synthesis of this linear biopolymer is unknown. Secondly, the low sensitivity and specificity of available polyP detection methods make it difficult to confidently ascertain polyP presence in mammalian cells, since in higher eukaryotes, polyP exists in lower amounts than in yeast or bacteria. Despite this, polyP has been given a remarkably large number of functions in mammals. In this review, we discuss some of the proposed functions of polyP in mammals, the limitations of the current detection methods and the urgent need to understand how this polymer is synthesized.
date: 2020-02-12
date_type: published
official_url: https://doi.org/10.1042/BST20190328
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1752556
doi: 10.1042/BST20190328
pii: 222097
lyricists_name: Desfougeres, Yann
lyricists_name: Saiardi, Adolfo
lyricists_id: YFDES94
lyricists_id: ASAIA50
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Biochemical Society Transactions
volume: 2020
article_number: BST20190328
event_location: England
citation:        Desfougères, Y;    Saiardi, A;    Azevedo, C;      (2020)    Inorganic polyphosphate in mammals: where's Wally?                   Biochemical Society Transactions , 2020     , Article BST20190328.  10.1042/BST20190328 <https://doi.org/10.1042/BST20190328>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10091801/1/bst-2019-0328c.pdf