%O Copyright © 2019 Society of Biological Psychiatry. This is an open access article under theCC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
%A SMC de Zwarte
%A RM Brouwer
%A I Agartz
%A M Alda
%A A Aleman
%A KI Alpert
%A CE Bearden
%A A Bertolino
%A C Bois
%A A Bonvino
%A E Bramon
%A EEL Buimer
%A W Cahn
%A DM Cannon
%A TD Cannon
%A X Caseras
%A J Castro-Fornieles
%A Q Chen
%A Y Chung
%A E De la Serna
%A A Di Giorgio
%A GE Doucet
%A MC Eker
%A S Erk
%A SC Fears
%A SF Foley
%A S Frangou
%A A Frankland
%A JM Fullerton
%A DC Glahn
%A VM Goghari
%A AL Goldman
%A AS Gonul
%A O Gruber
%A L de Haan
%A T Hajek
%A EL Hawkins
%A A Heinz
%A MHJ Hillegers
%A HEH Pol
%A CM Hultman
%A M Ingvar
%A V Johansson
%A EG Jonsson
%A F Kane
%A MJ Kempton
%A MMG Koenis
%A M Kopecek
%A L Krabbendam
%A B Kraemer
%A SM Lawrie
%A RK Lenroot
%A M Marcelis
%A J-BC Marsman
%A VS Mattay
%A C McDonald
%A A Meyer-Lindenberg
%A S Michielse
%A PB Mitchell
%A D Moreno
%A RM Murray
%A B Mwangi
%A P Najt
%A E Neilson
%A J Newport
%A J van Os
%A B Overs
%A A Ozerdem
%A MM Picchioni
%A A Richter
%A G Roberts
%A AS Aydogan
%A PR Schofield
%A F Simsek
%A JC Soares
%A G Sugranyes
%A T Toulopoulou
%A G Tronchin
%A H Walter
%A L Wang
%A DR Weinberger
%A HC Whalley
%A N Yalin
%A OA Andreassen
%A CRK Ching
%A TGM van Erp
%A JA Turner
%A N Jahanshad
%A PM Thompson
%A RS Kahn
%A NEM van Haren
%J Biological Psychiatry
%L discovery10091739
%I ELSEVIER SCIENCE INC
%X BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities
are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain
abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with
bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater
volumes compared with control subjects.
METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ,
852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34
schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a
correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.
RESULTS: FDRs-BD had significantly larger ICV (d = 10.16, q , .05 corrected), whereas FDRs-SZ showed smaller
thalamic volumes than control subjects (d = 20.12, q , .05 corrected). ICV explained the enlargements in the brain
measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter,
cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d
, 20.09, q , .05 corrected); and third ventricle was larger (d = 10.15, q , .05 corrected). The findings were not
explained by psychopathology in the relatives or control subjects.
CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural
brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories
leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
%K Bipolar disorder, Familial risk, Imaging, Meta-analysis, Neurodevelopment, Schizophrenia
%T The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder
%N 7
%D 2019
%P 545-556
%V 86