%0 Journal Article
%@ 1873-2402
%A de Zwarte, SMC
%A Brouwer, RM
%A Agartz, I
%A Alda, M
%A Aleman, A
%A Alpert, KI
%A Bearden, CE
%A Bertolino, A
%A Bois, C
%A Bonvino, A
%A Bramon, E
%A Buimer, EEL
%A Cahn, W
%A Cannon, DM
%A Cannon, TD
%A Caseras, X
%A Castro-Fornieles, J
%A Chen, Q
%A Chung, Y
%A De la Serna, E
%A Di Giorgio, A
%A Doucet, GE
%A Eker, MC
%A Erk, S
%A Fears, SC
%A Foley, SF
%A Frangou, S
%A Frankland, A
%A Fullerton, JM
%A Glahn, DC
%A Goghari, VM
%A Goldman, AL
%A Gonul, AS
%A Gruber, O
%A de Haan, L
%A Hajek, T
%A Hawkins, EL
%A Heinz, A
%A Hillegers, MHJ
%A Pol, HEH
%A Hultman, CM
%A Ingvar, M
%A Johansson, V
%A Jonsson, EG
%A Kane, F
%A Kempton, MJ
%A Koenis, MMG
%A Kopecek, M
%A Krabbendam, L
%A Kraemer, B
%A Lawrie, SM
%A Lenroot, RK
%A Marcelis, M
%A Marsman, J-BC
%A Mattay, VS
%A McDonald, C
%A Meyer-Lindenberg, A
%A Michielse, S
%A Mitchell, PB
%A Moreno, D
%A Murray, RM
%A Mwangi, B
%A Najt, P
%A Neilson, E
%A Newport, J
%A van Os, J
%A Overs, B
%A Ozerdem, A
%A Picchioni, MM
%A Richter, A
%A Roberts, G
%A Aydogan, AS
%A Schofield, PR
%A Simsek, F
%A Soares, JC
%A Sugranyes, G
%A Toulopoulou, T
%A Tronchin, G
%A Walter, H
%A Wang, L
%A Weinberger, DR
%A Whalley, HC
%A Yalin, N
%A Andreassen, OA
%A Ching, CRK
%A van Erp, TGM
%A Turner, JA
%A Jahanshad, N
%A Thompson, PM
%A Kahn, RS
%A van Haren, NEM
%D 2019
%F discovery:10091739
%I ELSEVIER SCIENCE INC
%J Biological Psychiatry
%K Bipolar disorder, Familial risk, Imaging, Meta-analysis, Neurodevelopment, Schizophrenia
%N 7
%P 545-556
%T The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder
%U https://discovery.ucl.ac.uk/id/eprint/10091739/
%V 86
%X BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities  are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain  abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with  bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater  volumes compared with control subjects.  METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ,  852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34  schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a  correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.  RESULTS: FDRs-BD had significantly larger ICV (d = 10.16, q , .05 corrected), whereas FDRs-SZ showed smaller  thalamic volumes than control subjects (d = 20.12, q , .05 corrected). ICV explained the enlargements in the brain  measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter,  cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d  , 20.09, q , .05 corrected); and third ventricle was larger (d = 10.15, q , .05 corrected). The findings were not  explained by psychopathology in the relatives or control subjects.  CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural  brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories  leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
%Z Copyright © 2019 Society of Biological Psychiatry. This is an open access article under theCC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).