<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10091419> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/title> "Comparative cardiovascular risk in users versus non-users of xanthine oxidase inhibitors and febuxostat versus allopurinol users"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/abstract> "OBJECTIVES: The aim of this study is to determine major adverse cardiovascular events (MACE) and all-cause mortality comparing between xanthine oxidase inhibitors (XOIs) and non-XOI users, and between allopurinol and febuxostat. METHODS: This is a retrospective cohort study of gout patients prescribed anti-hyperuricemic medications between 2013 and 2017 using a territory-wide administrative database. XOI users were matched 1:1 to XOI non-users using propensity scores. Febuxostat users were matched 1:3 to allopurinol users. Subgroup analyses were conducted based on colchicine use. RESULTS: Of the 13 997 eligible participants, 3607 (25.8%) were XOI users and 10 390 (74.2%) were XOI non-users. After propensity score matching, compared with non-users (n = 3607), XOI users (n = 3607) showed similar incidence of MACE (hazard ratio [HR]: 0.997, 95% CI, 0.879, 1.131; P>0.05) and all-cause mortality (HR = 0.972, 95% CI 0.886, 1.065, P=0.539). Febuxostat (n = 276) users showed a similar risk of MACE compared with allopurinol users (n = 828; HR: 0.672, 95% CI, 0.416, 1.085; P=0.104) with a tendency towards a lower risk of heart failure-related hospitalizations (HR = 0.529, 95% CI 0.272, 1.029; P=0.061). Concurrent colchicine use reduced the risk for all-cause mortality amongst XOI users (HR = 0.671, 95% 0.586, 0.768; P<0.001). CONCLUSION: In gout patients, XOI users showed similar risk of MACE and all-cause mortality compared with non-users. Compared with allopurinol users, febuxostat users showed similar MACE and all-cause mortality risks but lower heart failure-related hospitalizations."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/date> "2020-09" .
<https://discovery.ucl.ac.uk/id/document/1051877> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/volume> "59" .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/issue> "9" .
<https://discovery.ucl.ac.uk/id/publication/ext-17e996020859af3dd68791c432d12c96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-17e996020859af3dd68791c432d12c96> <http://xmlns.com/foaf/0.1/name> "Rheumatology"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-17e996020859af3dd68791c432d12c96> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1523f8e93a0e1ef2cec578adf4bfc518> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-1523f8e93a0e1ef2cec578adf4bfc518> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-900435392272dd35ccb7f5754cce8070> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-900435392272dd35ccb7f5754cce8070> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-65f0e1a68c8cacff73736190e3dee298> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-65f0e1a68c8cacff73736190e3dee298> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c6380d9fc9569347ff5530e54f35c550> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-c6380d9fc9569347ff5530e54f35c550> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a61eebb09f4e890088aeed9d5430a125> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-a61eebb09f4e890088aeed9d5430a125> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cf775092efe53255bee86503b182d533> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-cf775092efe53255bee86503b182d533> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d80f56d6298f4375e02ee72c7a1c015b> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-d80f56d6298f4375e02ee72c7a1c015b> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c1fd4cce37b8e220732e9de2eb35592e> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-c1fd4cce37b8e220732e9de2eb35592e> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-c92754c735eeca29274f9a82f2d1a29b> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-c92754c735eeca29274f9a82f2d1a29b> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-f53fcc6d80c77ee76c32a5eedc876c96> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-f53fcc6d80c77ee76c32a5eedc876c96> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-54481ad70fd85d5442bac332d0b9bbb1> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-54481ad70fd85d5442bac332d0b9bbb1> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-2ab63a5f0140763c83e79e1810ff5f07> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-2ab63a5f0140763c83e79e1810ff5f07> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-626e1b007c370e7a139ab754b60f2a67> .
<https://discovery.ucl.ac.uk/id/eprint/10091419> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10091419#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10091419#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-626e1b007c370e7a139ab754b60f2a67> .
<https://discovery.ucl.ac.uk/id/person/ext-cf775092efe53255bee86503b182d533> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-cf775092efe53255bee86503b182d533> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cf775092efe53255bee86503b182d533> <http://xmlns.com/foaf/0.1/familyName> "Ho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-cf775092efe53255bee86503b182d533> <http://xmlns.com/foaf/0.1/name> "J Ho"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-54481ad70fd85d5442bac332d0b9bbb1> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-54481ad70fd85d5442bac332d0b9bbb1> <http://xmlns.com/foaf/0.1/givenName> "ICK"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-54481ad70fd85d5442bac332d0b9bbb1> <http://xmlns.com/foaf/0.1/familyName> "Wong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-54481ad70fd85d5442bac332d0b9bbb1> <http://xmlns.com/foaf/0.1/name> "ICK Wong"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-900435392272dd35ccb7f5754cce8070> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-900435392272dd35ccb7f5754cce8070> <http://xmlns.com/foaf/0.1/givenName> "RWC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-900435392272dd35ccb7f5754cce8070> <http://xmlns.com/foaf/0.1/familyName> "Lai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-900435392272dd35ccb7f5754cce8070> <http://xmlns.com/foaf/0.1/name> "RWC Lai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-65f0e1a68c8cacff73736190e3dee298> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-65f0e1a68c8cacff73736190e3dee298> <http://xmlns.com/foaf/0.1/givenName> "KHC"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-65f0e1a68c8cacff73736190e3dee298> <http://xmlns.com/foaf/0.1/familyName> "Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-65f0e1a68c8cacff73736190e3dee298> <http://xmlns.com/foaf/0.1/name> "KHC Li"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d80f56d6298f4375e02ee72c7a1c015b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d80f56d6298f4375e02ee72c7a1c015b> <http://xmlns.com/foaf/0.1/givenName> "Y"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d80f56d6298f4375e02ee72c7a1c015b> <http://xmlns.com/foaf/0.1/familyName> "Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d80f56d6298f4375e02ee72c7a1c015b> <http://xmlns.com/foaf/0.1/name> "Y Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-626e1b007c370e7a139ab754b60f2a67> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-626e1b007c370e7a139ab754b60f2a67> <http://xmlns.com/foaf/0.1/givenName> "G"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-626e1b007c370e7a139ab754b60f2a67> <http://xmlns.com/foaf/0.1/familyName> "Tse"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-626e1b007c370e7a139ab754b60f2a67> <http://xmlns.com/foaf/0.1/name> "G Tse"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ab63a5f0140763c83e79e1810ff5f07> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-2ab63a5f0140763c83e79e1810ff5f07> <http://xmlns.com/foaf/0.1/givenName> "LS"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ab63a5f0140763c83e79e1810ff5f07> <http://xmlns.com/foaf/0.1/familyName> "Tam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-2ab63a5f0140763c83e79e1810ff5f07> <http://xmlns.com/foaf/0.1/name> "LS Tam"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f53fcc6d80c77ee76c32a5eedc876c96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-f53fcc6d80c77ee76c32a5eedc876c96> <http://xmlns.com/foaf/0.1/givenName> "BMY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f53fcc6d80c77ee76c32a5eedc876c96> <http://xmlns.com/foaf/0.1/familyName> "Cheung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-f53fcc6d80c77ee76c32a5eedc876c96> <http://xmlns.com/foaf/0.1/name> "BMY Cheung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c92754c735eeca29274f9a82f2d1a29b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c92754c735eeca29274f9a82f2d1a29b> <http://xmlns.com/foaf/0.1/givenName> "T"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c92754c735eeca29274f9a82f2d1a29b> <http://xmlns.com/foaf/0.1/familyName> "Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c92754c735eeca29274f9a82f2d1a29b> <http://xmlns.com/foaf/0.1/name> "T Liu"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a61eebb09f4e890088aeed9d5430a125> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-a61eebb09f4e890088aeed9d5430a125> <http://xmlns.com/foaf/0.1/givenName> "JCL"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a61eebb09f4e890088aeed9d5430a125> <http://xmlns.com/foaf/0.1/familyName> "Lai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-a61eebb09f4e890088aeed9d5430a125> <http://xmlns.com/foaf/0.1/name> "JCL Lai"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6380d9fc9569347ff5530e54f35c550> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c6380d9fc9569347ff5530e54f35c550> <http://xmlns.com/foaf/0.1/givenName> "JKF"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6380d9fc9569347ff5530e54f35c550> <http://xmlns.com/foaf/0.1/familyName> "Hung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c6380d9fc9569347ff5530e54f35c550> <http://xmlns.com/foaf/0.1/name> "JKF Hung"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1523f8e93a0e1ef2cec578adf4bfc518> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1523f8e93a0e1ef2cec578adf4bfc518> <http://xmlns.com/foaf/0.1/givenName> "C"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1523f8e93a0e1ef2cec578adf4bfc518> <http://xmlns.com/foaf/0.1/familyName> "Ju"^^<http://www.w3.org/2001/XMLSchema#string> .
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