eprintid: 10091209
rev_number: 28
eprint_status: archive
userid: 608
dir: disk0/10/09/12/09
datestamp: 2020-02-17 16:39:58
lastmod: 2021-09-17 22:16:56
status_changed: 2020-02-17 16:39:58
type: article
metadata_visibility: show
creators_name: Tinazzi, M
creators_name: Squintani, GM
creators_name: Bhatia, KP
creators_name: Segatti, A
creators_name: Donato, F
creators_name: Valeriani, M
creators_name: Erro, R
title: Pain in cervical dystonia: Evidence of abnormal inhibitory control
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Diffuse noxious inhibitory control, Laser evoked potentials, Dystonia
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Introduction: Several observations would suggest that dystonic pain is not simply muscular in origin. While ascending nociceptive pathways are normal in cervical dystonia, it is unknown whether descending inhibitory pain pathways are also normal. /

Methods: We applied a conditioned pain modulation protocol and concomitantly recorded laser evoked potentials in patients with cervical dystonia (n = 15), blepharospasm (n = 15) and healthy volunteers (n = 15). /

Results: During the application of a heterotopic noxious conditioning stimulation, patients with cervical dystonia, but not with blepharospasm, lacked the physiological reduction of the perceived intensity of a painful test stimulus as well as of the related evoked potential. This was observed in cervical dystonia patients regardless of the presence of clinical pain. /

Conclusions: Our results suggest that pain in CD is not simply muscular in origin but it also possibly reflects a dysfunction of the descending pain inhibitory control, thus providing a novel venue to explore the pathophysiology of pain in CD.
date: 2019-08
date_type: published
publisher: ELSEVIER SCI LTD
official_url: https://doi.org/10.1016/j.parkreldis.2019.06.009
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1667841
doi: 10.1016/j.parkreldis.2019.06.009
lyricists_name: Bhatia, Kailash
lyricists_id: KPBHA96
actors_name: Allington-Smith, Dominic
actors_id: DAALL44
actors_role: owner
full_text_status: public
publication: Parkinsonism & Related Disorders
volume: 65
pagerange: 252-255
pages: 4
citation:        Tinazzi, M;    Squintani, GM;    Bhatia, KP;    Segatti, A;    Donato, F;    Valeriani, M;    Erro, R;      (2019)    Pain in cervical dystonia: Evidence of abnormal inhibitory control.                   Parkinsonism & Related Disorders , 65    pp. 252-255.    10.1016/j.parkreldis.2019.06.009 <https://doi.org/10.1016/j.parkreldis.2019.06.009>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10091209/6/Bhatia_Pain%20in%20cervical%20dystonia%20Evidence%20of%20abnormal%20inhibitory%20control_combined.pdf