eprintid: 10090515 rev_number: 19 eprint_status: archive userid: 608 dir: disk0/10/09/05/15 datestamp: 2020-01-28 14:43:55 lastmod: 2021-12-18 23:55:00 status_changed: 2020-01-28 14:43:55 type: article metadata_visibility: show creators_name: Marlais, M creators_name: Stojanovic, J creators_name: Jones, H creators_name: Cleghorn, S creators_name: Rees, L title: Catch-up growth in children with chronic kidney disease started on enteral feeding after 2 years of age ispublished: pub subjects: GOSH divisions: UCL divisions: B02 divisions: D13 divisions: G22 keywords: Pediatrics, Urology & Nephrology, Paediatrics, Chronic kidney disease, Growth, Enteral feeding, Gastrostomy note: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/). abstract: BACKGROUND: Enteral feeding by tube in chronic kidney disease (CKD) before 2 years of age improves growth. Whether it is effective after this age is unknown. We assessed whether height and weight SDS changed after tube feeding was started in children with CKD above 2 years of age. METHODS: Retrospective study of pre-transplant, pre-pubertal children (< 11 years) with CKD stages 2–5 started on nasogastric tube or gastrostomy feeds for the first time after age 2 years. Children were identified by searching dietetic records and the renal database. Children on growth hormone were excluded. Height, weight, and BMI were documented 1 year prior to and at the start of tube feeds, and after 1 and 2 years. Data collection ceased at transplantation. RESULTS: Fifty children (25 male) were included. The median (range) age at start of tube feeds was 5.6 (2.1–10.9) years. Sixteen children were dialysed (1 haemodialysis, 15 peritoneal dialysis); 34 predialysis patients had a median (range) eGFR of 22 (6–88) ml/min/1.73 m2. Overall height SDS (Ht SDS) improved from − 2.39 to − 2.27 at 1 year and − 2.18 after 2 years (p = 0.02). BMI SDS improved from − 0.72 to 0.23 after 1 year and was 0.09 after 2 years of enteral feeding (p < 0.0001). Height SDS improved more in children aged 2–6 years (− 2.13 to − 1.68, p = 0.03) and in children not on dialysis (− 2.33 to − 1.99, p = 0.002). CONCLUSIONS: Enteral tube feeding commenced after 2 years of age in prepubertal children with CKD improves height and weight SDS, with stability of BMI during the second year. Younger children and those not on dialysis had the greatest benefit. date: 2020-01 date_type: published publisher: SPRINGER official_url: https://doi.org/10.1007/s00467-019-04382-9 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1711777 doi: 10.1007/s00467-019-04382-9 lyricists_name: Marlais, Matko lyricists_name: Rees, Lesley lyricists_id: MMARL97 lyricists_id: LREES55 actors_name: Zahnhausen-Stuber, Petra actors_id: PMZAH20 actors_role: owner full_text_status: public publication: Pediatric Nephrology volume: 35 number: 1 pagerange: 113-118 pages: 6 issn: 0931-041X citation: Marlais, M; Stojanovic, J; Jones, H; Cleghorn, S; Rees, L; (2020) Catch-up growth in children with chronic kidney disease started on enteral feeding after 2 years of age. Pediatric Nephrology , 35 (1) pp. 113-118. 10.1007/s00467-019-04382-9 <https://doi.org/10.1007/s00467-019-04382-9>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10090515/1/Catch-up%20growth%20in%20children%20with%20chronic%20kidney%20disease%20started%20on%20enteral%20feeding%20after%202%20years%20of%20age.pdf