eprintid: 10090515
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/09/05/15
datestamp: 2020-01-28 14:43:55
lastmod: 2021-12-18 23:55:00
status_changed: 2020-01-28 14:43:55
type: article
metadata_visibility: show
creators_name: Marlais, M
creators_name: Stojanovic, J
creators_name: Jones, H
creators_name: Cleghorn, S
creators_name: Rees, L
title: Catch-up growth in children with chronic kidney disease started on enteral feeding after 2 years of age
ispublished: pub
subjects: GOSH
divisions: UCL
divisions: B02
divisions: D13
divisions: G22
keywords: Pediatrics, Urology & Nephrology, Paediatrics, Chronic kidney disease, Growth, Enteral feeding, Gastrostomy
note: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
abstract: BACKGROUND: Enteral feeding by tube in chronic kidney disease (CKD) before 2 years of age improves growth. Whether it is effective after this age is unknown. We assessed whether height and weight SDS changed after tube feeding was started in children with CKD above 2 years of age. METHODS: Retrospective study of pre-transplant, pre-pubertal children (< 11 years) with CKD stages 2–5 started on nasogastric tube or gastrostomy feeds for the first time after age 2 years. Children were identified by searching dietetic records and the renal database. Children on growth hormone were excluded. Height, weight, and BMI were documented 1 year prior to and at the start of tube feeds, and after 1 and 2 years. Data collection ceased at transplantation. RESULTS: Fifty children (25 male) were included. The median (range) age at start of tube feeds was 5.6 (2.1–10.9) years. Sixteen children were dialysed (1 haemodialysis, 15 peritoneal dialysis); 34 predialysis patients had a median (range) eGFR of 22 (6–88) ml/min/1.73 m2. Overall height SDS (Ht SDS) improved from − 2.39 to − 2.27 at 1 year and − 2.18 after 2 years (p = 0.02). BMI SDS improved from − 0.72 to 0.23 after 1 year and was 0.09 after 2 years of enteral feeding (p < 0.0001). Height SDS improved more in children aged 2–6 years (− 2.13 to − 1.68, p = 0.03) and in children not on dialysis (− 2.33 to − 1.99, p = 0.002). CONCLUSIONS: Enteral tube feeding commenced after 2 years of age in prepubertal children with CKD improves height and weight SDS, with stability of BMI during the second year. Younger children and those not on dialysis had the greatest benefit.
date: 2020-01
date_type: published
publisher: SPRINGER
official_url: https://doi.org/10.1007/s00467-019-04382-9
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1711777
doi: 10.1007/s00467-019-04382-9
lyricists_name: Marlais, Matko
lyricists_name: Rees, Lesley
lyricists_id: MMARL97
lyricists_id: LREES55
actors_name: Zahnhausen-Stuber, Petra
actors_id: PMZAH20
actors_role: owner
full_text_status: public
publication: Pediatric Nephrology
volume: 35
number: 1
pagerange: 113-118
pages: 6
issn: 0931-041X
citation:        Marlais, M;    Stojanovic, J;    Jones, H;    Cleghorn, S;    Rees, L;      (2020)    Catch-up growth in children with chronic kidney disease started on enteral feeding after 2 years of age.                   Pediatric Nephrology , 35  (1)   pp. 113-118.    10.1007/s00467-019-04382-9 <https://doi.org/10.1007/s00467-019-04382-9>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10090515/1/Catch-up%20growth%20in%20children%20with%20chronic%20kidney%20disease%20started%20on%20enteral%20feeding%20after%202%20years%20of%20age.pdf