eprintid: 10090484
rev_number: 31
eprint_status: archive
userid: 608
dir: disk0/10/09/04/84
datestamp: 2020-01-31 16:01:19
lastmod: 2021-10-02 00:04:19
status_changed: 2020-02-13 16:04:48
type: article
metadata_visibility: show
creators_name: Dickenson, AH
creators_name: Patel, R
title: Translational issues in precision medicine in neuropathic pain
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D09
divisions: G02
keywords: Translational research, neuropathic pain, sensory phenotype, precision medicine, animal models of neuropathy
note: © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Neuropathic pain remains poorly treated with most new drugs falling through the translational gap. The traditional model of bench-to-bedside research has relied on identifying new mechanisms/targets in animal models and then developing clinical applications. Several have advocated bridging the translational gap by beginning with clinical observations and back-translating to animal models for further investigation of mechanisms. There is good evidence that phenotyping of patients through quantitative sensory testing can lead to improved treatment selection and hence improved patient outcomes. These practices have been widely adopted in clinical investigations but its application in pre-clinical research is not mainstream. In this review, we retrospectively examine our historical rodent datasets with the aim of reconsidering drug effects on sensory neuronal endpoints, their alignment with clinical observations and how these might guide future clinical studies.
date: 2020-01-23
publisher: Informa UK Limited
official_url: https://doi.org/10.1080/24740527.2020.1720502
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1745033
doi: 10.1080/24740527.2020.1720502
lyricists_name: Dickenson, Anthony
lyricists_name: Patel, Ryan
lyricists_id: AHDIC08
lyricists_id: RPATA65
actors_name: Patel, Ryan
actors_id: RPATA65
actors_role: owner
full_text_status: public
publication: Canadian Journal of Pain
volume: 4
number: 1
pagerange: 30-38
citation:        Dickenson, AH;    Patel, R;      (2020)    Translational issues in precision medicine in neuropathic pain.                   Canadian Journal of Pain , 4  (1)   pp. 30-38.    10.1080/24740527.2020.1720502 <https://doi.org/10.1080/24740527.2020.1720502>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10090484/8/Patel_Translational%20issues%20in%20precision%20medicine%20in%20neuropathic%20pain.pdf