eprintid: 10090484 rev_number: 31 eprint_status: archive userid: 608 dir: disk0/10/09/04/84 datestamp: 2020-01-31 16:01:19 lastmod: 2021-10-02 00:04:19 status_changed: 2020-02-13 16:04:48 type: article metadata_visibility: show creators_name: Dickenson, AH creators_name: Patel, R title: Translational issues in precision medicine in neuropathic pain ispublished: pub divisions: UCL divisions: B02 divisions: C08 divisions: D09 divisions: G02 keywords: Translational research, neuropathic pain, sensory phenotype, precision medicine, animal models of neuropathy note: © 2020 The Author(s). Published with license by Taylor & Francis Group, LLC. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: Neuropathic pain remains poorly treated with most new drugs falling through the translational gap. The traditional model of bench-to-bedside research has relied on identifying new mechanisms/targets in animal models and then developing clinical applications. Several have advocated bridging the translational gap by beginning with clinical observations and back-translating to animal models for further investigation of mechanisms. There is good evidence that phenotyping of patients through quantitative sensory testing can lead to improved treatment selection and hence improved patient outcomes. These practices have been widely adopted in clinical investigations but its application in pre-clinical research is not mainstream. In this review, we retrospectively examine our historical rodent datasets with the aim of reconsidering drug effects on sensory neuronal endpoints, their alignment with clinical observations and how these might guide future clinical studies. date: 2020-01-23 publisher: Informa UK Limited official_url: https://doi.org/10.1080/24740527.2020.1720502 oa_status: green full_text_type: pub language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1745033 doi: 10.1080/24740527.2020.1720502 lyricists_name: Dickenson, Anthony lyricists_name: Patel, Ryan lyricists_id: AHDIC08 lyricists_id: RPATA65 actors_name: Patel, Ryan actors_id: RPATA65 actors_role: owner full_text_status: public publication: Canadian Journal of Pain volume: 4 number: 1 pagerange: 30-38 citation: Dickenson, AH; Patel, R; (2020) Translational issues in precision medicine in neuropathic pain. Canadian Journal of Pain , 4 (1) pp. 30-38. 10.1080/24740527.2020.1720502 <https://doi.org/10.1080/24740527.2020.1720502>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10090484/8/Patel_Translational%20issues%20in%20precision%20medicine%20in%20neuropathic%20pain.pdf