eprintid: 10090006
rev_number: 40
eprint_status: archive
userid: 608
dir: disk0/10/09/00/06
datestamp: 2020-01-21 14:34:36
lastmod: 2021-12-03 23:09:40
status_changed: 2020-01-21 14:34:36
type: article
metadata_visibility: show
creators_name: Shallcross, L
creators_name: Lorencatto, F
creators_name: Fuller, C
creators_name: Tarrant, C
creators_name: West, J
creators_name: Traina, R
creators_name: Smith, C
creators_name: Forbes, G
creators_name: Crayton, E
creators_name: Rockenschaub, P
creators_name: Dutey-Magni, P
creators_name: Richardson, E
creators_name: Fragaszy, E
creators_name: Michie, S
creators_name: Hayward, A
title: An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme [version 1; peer review: 2 approved]
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D05
divisions: F66
divisions: C08
divisions: D10
divisions: G11
divisions: D12
divisions: G19
divisions: DD4
divisions: B04
divisions: C06
divisions: ZZ3
keywords: Antimicrobial-stewardship, behaviour-change, interdisciplinary, ethnography, epidemiology, user-centred design
note: © 2020 Shallcross L et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: Behaviour change is key to combating antimicrobial resistance. Antimicrobial stewardship (AMS) programmes promote and monitor judicious antibiotic use, but there is little consideration of behavioural and social influences when designing interventions.  We outline a programme of research which aims to co-design AMS interventions across healthcare settings, by integrating data-science, evidence- synthesis, behavioural-science and user-centred design.
The project includes three work-packages (WP):
WP1 (Identifying patterns of prescribing):  analysis of electronic health-records to identify prescribing patterns in care-homes, primary-care, and secondary-care. An online survey will investigate consulting/antibiotic-seeking behaviours in members of the public.
WP2 (Barriers and enablers to prescribing in practice): Semi-structured interviews and observations of practice to identify barriers/enablers to prescribing, influences on antibiotic-seeking behaviour and the social/contextual factors underpinning prescribing. Systematic reviews of AMS interventions to identify the components of existing interventions associated with effectiveness. Design workshops to identify constraints influencing the form of the intervention. Interviews conducted with healthcare-professionals in community pharmacies, care-homes, primary-, and secondary-care and with members of the public. Topic guides and analysis based on the Theoretical Domains Framework.  Observations conducted in care-homes, primary and secondary-care with analysis drawing on grounded theory.  Systematic reviews of interventions in each setting will be conducted, and interventions described using the Behaviour Change Technique taxonomy v1. Design workshops in care-homes, primary-, and secondary care.
WP3 (Co-production of interventions and dissemination). Findings will be integrated to identify opportunities for interventions, and assess whether existing interventions target influences on antibiotic use. Stakeholder panels will be assembled to co-design and refine interventions in each setting, applying the Affordability, Practicability, Effectiveness, Acceptability, Side-effects and Equity (APEASE) criteria to prioritise candidate interventions. 
Outputs will inform development of new AMS interventions and/or optimisation of existing interventions.  We will also develop web-resources for stakeholders providing analyses of antibiotic prescribing patterns, prescribing behaviours, and evidence reviews.
date: 2020-01-14
date_type: published
publisher: F1000 Research Ltd
official_url: http://dx.doi.org/10.12688/wellcomeopenres.15554.1
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1742857
doi: 10.12688/wellcomeopenres.15554.1
lyricists_name: Atkins, Louise
lyricists_name: Crayton, Elise
lyricists_name: Dutey-Magni, Pierre
lyricists_name: Fragaszy, Ellen
lyricists_name: Fuller, Christopher
lyricists_name: Hayward, Andrew
lyricists_name: Horne, Robert
lyricists_name: Kostkova, Patricie
lyricists_name: Lorencatto, Fabiana
lyricists_name: Michie, Susan
lyricists_name: Mindell, Jennifer
lyricists_name: Rockenschaub, Patrick
lyricists_name: Shallcross, Laura
lyricists_name: Smith, Catherine
lyricists_id: LATKI71
lyricists_id: ECRAY38
lyricists_id: PFDUT15
lyricists_id: EFRAG24
lyricists_id: CFULL14
lyricists_id: ACHAY31
lyricists_id: RHORN95
lyricists_id: PKOST97
lyricists_id: FRLOR99
lyricists_id: SFMIC21
lyricists_id: JMIND63
lyricists_id: PROCK50
lyricists_id: LSHAL65
lyricists_id: CSMIT61
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Wellcome Open Research
volume: 5
article_number: 8
issn: 2398-502X
citation:        Shallcross, L;    Lorencatto, F;    Fuller, C;    Tarrant, C;    West, J;    Traina, R;    Smith, C;                                 ... Hayward, A; + view all <#>        Shallcross, L;  Lorencatto, F;  Fuller, C;  Tarrant, C;  West, J;  Traina, R;  Smith, C;  Forbes, G;  Crayton, E;  Rockenschaub, P;  Dutey-Magni, P;  Richardson, E;  Fragaszy, E;  Michie, S;  Hayward, A;   - view fewer <#>    (2020)    An interdisciplinary mixed-methods approach to developing antimicrobial stewardship interventions: Protocol for the Preserving Antibiotics through Safe Stewardship (PASS) Research Programme [version 1; peer review: 2 approved].                   Wellcome Open Research , 5     , Article 8.  10.12688/wellcomeopenres.15554.1 <https://doi.org/10.12688/wellcomeopenres.15554.1>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10090006/1/1a1f5913-314e-480a-991c-baf139053d81_15554_-_christopher_fuller.pdf