eprintid: 10089787
rev_number: 23
eprint_status: archive
userid: 608
dir: disk0/10/08/97/87
datestamp: 2020-01-17 15:31:42
lastmod: 2021-09-17 22:01:32
status_changed: 2020-01-17 15:31:42
type: article
metadata_visibility: show
creators_name: Cavedo, E
creators_name: Lista, S
creators_name: Houot, M
creators_name: Vergallo, A
creators_name: Grothe, MJ
creators_name: Teipel, S
creators_name: Zetterberg, H
creators_name: Blennow, K
creators_name: Habert, M-O
creators_name: Potier, MC
creators_name: Dubois, B
creators_name: Hampel, H
creators_name: INSIGHT-preAD Study Group and the Alzheimer Precision Medicine I, 
title: Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F86
keywords: Alzheimer's disease, Volumetric MRI
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: OBJECTIVE: To investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD). METHODS: This was a large-scale study of 276 cognitively intact older adults from the monocentric INSIGHT-preAD (Investigation of Alzheimer's Predictors in Subjective Memory Complainers) cohort. Participants underwent baseline assessment of plasma t-tau and NfL concentrations as well as baseline and 24-month follow-up MRI scans. Linear models with and without influential observations (calculated using the Cook distance) were carried out to investigate the effect of plasma NfL and t-tau concentrations, and their interaction effect with β-amyloid status and APOE genotype, on the APC of the whole BFCS and its anterior (Ch1/2) and posterior (Ch4) subdivisions separately. RESULTS: Higher plasma t-tau concentrations at baseline were associated with higher BFCS rate of atrophy (model without influencers: n = 251, F value = 4.6815; p value = 0.031). Subregional analyses showed similar results for both the APC of the Ch1/2 (model without influencers: n = 256, F value = 3.9535, p corrected = 0.047) and Ch4 BFCS sectors (model without influencers: n = 253, F value = 4.9090, p corrected = 0.047). Baseline NfL, β-amyloid load, and APOE ε4 carrier status did not affect APC of the BFCS. CONCLUSION: Increased concentrations of baseline plasma t-tau may predict in vivo structural BFCS atrophy progression in older adults at risk for AD, independently of β-amyloid status and APOE genotype.
date: 2020-01-07
date_type: published
official_url: https://doi.org/10.1212/WNL.0000000000008696
full_text_type: other
language: eng
verified: verified_manual
elements_id: 1729556
doi: 10.1212/WNL.0000000000008696
pii: WNL.0000000000008696
lyricists_name: Zetterberg, Henrik
lyricists_id: HZETT94
actors_name: Allington-Smith, Dominic
actors_id: DAALL44
actors_role: owner
full_text_status: restricted
publication: Neurology
volume: 94
number: 1
pagerange: e30-e41
event_location: United States
citation:        Cavedo, E;    Lista, S;    Houot, M;    Vergallo, A;    Grothe, MJ;    Teipel, S;    Zetterberg, H;                         ... INSIGHT-preAD Study Group and the Alzheimer Precision Medicine I; + view all <#>        Cavedo, E;  Lista, S;  Houot, M;  Vergallo, A;  Grothe, MJ;  Teipel, S;  Zetterberg, H;  Blennow, K;  Habert, M-O;  Potier, MC;  Dubois, B;  Hampel, H;  INSIGHT-preAD Study Group and the Alzheimer Precision Medicine I;   - view fewer <#>    (2020)    Plasma tau correlates with basal forebrain atrophy rates in people at risk for Alzheimer disease.                   Neurology , 94  (1)   e30-e41.    10.1212/WNL.0000000000008696 <https://doi.org/10.1212/WNL.0000000000008696>.      
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10089787/3/Zetterberg_Cavedo.pdf