eprintid: 10088513 rev_number: 31 eprint_status: archive userid: 608 dir: disk0/10/08/85/13 datestamp: 2020-01-09 13:30:53 lastmod: 2021-11-30 23:03:37 status_changed: 2021-01-25 18:00:06 type: article metadata_visibility: show creators_name: Stolfo, D creators_name: Uijl, A creators_name: Benson, L creators_name: Schrage, B creators_name: Fudim, M creators_name: Asselbergs, FW creators_name: Koudstaal, S creators_name: Sinagra, G creators_name: Dahlstroem, U creators_name: Rosano, G creators_name: Savarese, G title: Association between beta‐blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score‐matched analysis from the Swedish Heart Failure Registry ispublished: pub divisions: UCL divisions: B02 divisions: DD4 keywords: Heart failure, Elderly, Beta-blocker, SwedeHF, Registry note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: BACKGROUND: Beta‐blockers reduce mortality and morbidity in heart failure (HF) with reduced ejection fraction (HFrEF). However, patients older than 80 years are poorly represented in randomized controlled trials. We assessed the association between beta‐blocker use and outcomes in HFrEF patients aged ≥80 years. METHODS AND RESULTS: We included patients with an ejection fraction <40% and aged ≥80 years from the Swedish HF Registry. The association between beta‐blocker use, all‐cause mortality and cardiovascular (CV) mortality/HF hospitalization was assessed by Cox proportional hazard models in a 1:1 propensity score‐matched cohort. To assess consistency, the same analyses were performed in a positive control cohort with age <80 years. A negative control outcome analysis was run using hospitalization for cancer as endpoint. Of 6562 patients aged ≥80 years, 5640 (86%) received beta‐blockers. In the matched cohort including 1732 patients, beta‐blocker use was associated with a significant reduction in the risk of all‐cause mortality [hazard ratio (HR) 0.89, 95% confidence interval (CI) 0.79–0.99]. Reduction in CV mortality/HF hospitalization was not significant (HR 0.94, 95% CI 0.85–1.05) due to the lack of association with HF hospitalization, whereas CV death was significantly reduced. After adjustment rather than matching for the propensity score in the overall cohort, beta‐blocker use was associated with reduced risk of all outcomes. In patients aged <80 years, use of beta‐blockers was associated with reduced risk of all‐cause death (HR 0.79, 95% CI 0.68–0.92) and of the composite outcome (HR 0.88, 95% CI 0.77–0.99). CONCLUSIONS: In HFrEF patients ≥80 years of age, use of beta‐blockers was high and was associated with improved all‐cause and CV survival. date: 2020-01 date_type: published publisher: WILEY official_url: https://doi.org/10.1002/ejhf.1615 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1716408 doi: 10.1002/ejhf.1615 lyricists_name: Asselbergs, Folkert lyricists_id: FASSE08 actors_name: Asselbergs, Folkert actors_id: FASSE08 actors_role: owner full_text_status: public publication: European Journal of Heart Failure volume: 22 number: 1 pagerange: 103-112 pages: 10 issn: 1879-0844 citation: Stolfo, D; Uijl, A; Benson, L; Schrage, B; Fudim, M; Asselbergs, FW; Koudstaal, S; ... Savarese, G; + view all <#> Stolfo, D; Uijl, A; Benson, L; Schrage, B; Fudim, M; Asselbergs, FW; Koudstaal, S; Sinagra, G; Dahlstroem, U; Rosano, G; Savarese, G; - view fewer <#> (2020) Association between beta‐blocker use and mortality/morbidity in older patients with heart failure with reduced ejection fraction. A propensity score‐matched analysis from the Swedish Heart Failure Registry. European Journal of Heart Failure , 22 (1) pp. 103-112. 10.1002/ejhf.1615 <https://doi.org/10.1002/ejhf.1615>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10088513/5/Asselbergs_Association%20between%20beta-blocker%20use%20and%20mortality%20or%20morbidity%20in%20older%20patients%20with%20heart%20failure%20with%20reduced%20ejection%20fraction_AAM2.pdf