%X This is a protocol for a Cochrane Review (Methodology). The objectives are as follows: The main objective of this systematic review of prospective empirical studies is to evaluate the benefits and disadvantages of trialâ€specific, riskâ€based monitoring strategies compared with a traditional intensive onâ€site monitoring strategy or other monitoring strategies for randomized and nonâ€randomized prospective intervention studies. %J Cochrane Database of Systematic Reviews %A K Klatte %A C Pauli-Magnus %A S Love %A M Sydes %A P Benkert %A N Bruni %A H Ewald %A P Arnaiz Jimenez %A MM Bonde %A M Briel %O This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. %I Wiley %L discovery10088236 %D 2019 %N 11 %T Monitoring strategies for clinical intervention studies