eprintid: 10087976
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/08/79/76
datestamp: 2019-12-16 14:47:45
lastmod: 2021-10-07 22:03:08
status_changed: 2019-12-16 14:47:45
type: article
metadata_visibility: show
creators_name: Casula, EP
creators_name: Maiella, M
creators_name: Pellicciari, MC
creators_name: Porrazzini, F
creators_name: D'Acunto, A
creators_name: Rocchi, L
creators_name: Koch, G
title: Novel TMS-EEG indexes to investigate interhemispheric dynamics in humans
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: EEG, Interhemispheric balance, Interhemispheric inhibition, TMS
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: OBJECTIVE: To validate two indexes of interhemispheric signal propagation (ISP) and balance (IHB) by combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG). METHODS: We used TMS-EEG to non-invasively stimulate the two hemispheres of 50 healthy volunteers and measured interhemispheric dynamics in terms of ISP and IHB. We repeated our evaluation after three weeks to assess the reliability of our indexes. We also tested whether our TMS-EEG measures were correlated with traditional interhemispheric inhibition (IHI), as measured with motor-evoked potentials (MEPs). RESULTS: Our main results showed that ISP and IHB (1) have a high reproducibility among all the participants tested; (2) have a high test-retest reliability (3) are linearly correlated with IHI, as measured with MEPs. CONCLUSIONS: The main contribution of this study lies in the proposal of new TMS-EEG cortical measures of interhemispheric dynamics and in their validation in terms of intra- and inter-subject reliability. We also provide the first demonstration of the correlation between ISP and IHI. SIGNIFICANCE: Our results are relevant for the investigation of interhemispheric dynamics in clinical populations where MEPs are not reliable.
date: 2020-01
date_type: published
official_url: https://doi.org/10.1016/j.clinph.2019.09.013
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1721081
doi: 10.1016/j.clinph.2019.09.013
pii: S1388-2457(19)31242-8
lyricists_name: Casula, Elias
lyricists_name: Rocchi, Lorenzo
lyricists_id: EPCAS14
lyricists_id: LROCC06
actors_name: Rocchi, Lorenzo
actors_id: LROCC06
actors_role: owner
full_text_status: public
publication: Clinical Neurophysiology
volume: 131
number: 1
pagerange: 70-77
event_location: Netherlands
issn: 1388-2457
citation:        Casula, EP;    Maiella, M;    Pellicciari, MC;    Porrazzini, F;    D'Acunto, A;    Rocchi, L;    Koch, G;      (2020)    Novel TMS-EEG indexes to investigate interhemispheric dynamics in humans.                   Clinical Neurophysiology , 131  (1)   pp. 70-77.    10.1016/j.clinph.2019.09.013 <https://doi.org/10.1016/j.clinph.2019.09.013>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10087976/3/Rocchi_Novel%20TMS-EEG%20indexes%20to%20investigate%20interhemispheric%20dynamics%20in%20humans_AAM.pdf