<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10087107> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/title> "Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/ontology/bibo/abstract> "A possible role for calcium signalling in the autosomal dominant form of dementia, familial encephalopathy with neuroserpin inclusion bodies (FENIB), has been proposed, which may point towards a mechanism by which cells could sense and respond to the accumulation of mutant serpin polymers in the endoplasmic reticulum (ER). We therefore explored possible defects in Ca2+-signalling, which may contribute to the pathology associated with another serpinopathy, α1-antitrypsin (AAT) deficiency. Using CHO K1 cell lines stably expressing a wild type human AAT (MAAT) and a disease-causing polymer-forming variant (ZAAT) and the truncated variant (NHK AAT), we measured basal intracellular free Ca2+, its responses to thapsigargin (TG), an ER Ca2+-ATPase blocker, and store-operated Ca2+-entry (SOCE). Our fura2 based Ca2+ measurements detected no differences between these 3 parameters in cell lines expressing MAAT and cell lines expressing ZAAT and NHK AAT mutants. Thus, in our cell-based models of α1-antitrypsin (AAT) deficiency, unlike the case for FENIB, we were unable to detect defects in calcium signalling."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/date> "2019-11-21" .
<https://discovery.ucl.ac.uk/id/document/1014907> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/ontology/bibo/volume> "9" .
<https://discovery.ucl.ac.uk/id/publication/ext-cadda8e76e894158e6af9ee5a82f3e8a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
<https://discovery.ucl.ac.uk/id/publication/ext-cadda8e76e894158e6af9ee5a82f3e8a> <http://xmlns.com/foaf/0.1/name> "Scientific Reports"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-cadda8e76e894158e6af9ee5a82f3e8a> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/ontology/bibo/status> <http://purl.org/ontology/bibo/status/published> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-7be5262d417e1fddfd67eebfef74373a> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10087107#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10087107#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_1> <https://discovery.ucl.ac.uk/id/person/ext-7be5262d417e1fddfd67eebfef74373a> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-d9fae245e54fa823f9362f698139b46d> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10087107#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10087107#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_2> <https://discovery.ucl.ac.uk/id/person/ext-d9fae245e54fa823f9362f698139b46d> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-eda909c489a2b8d046526996f02e4052> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10087107#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10087107#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_3> <https://discovery.ucl.ac.uk/id/person/ext-eda909c489a2b8d046526996f02e4052> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-990245c044c58ce77f8600013e836153> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10087107#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10087107#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-990245c044c58ce77f8600013e836153> .
<https://discovery.ucl.ac.uk/id/person/ext-eda909c489a2b8d046526996f02e4052> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-eda909c489a2b8d046526996f02e4052> <http://xmlns.com/foaf/0.1/givenName> "DA"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eda909c489a2b8d046526996f02e4052> <http://xmlns.com/foaf/0.1/familyName> "Lomas"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-eda909c489a2b8d046526996f02e4052> <http://xmlns.com/foaf/0.1/name> "DA Lomas"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7be5262d417e1fddfd67eebfef74373a> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-7be5262d417e1fddfd67eebfef74373a> <http://xmlns.com/foaf/0.1/givenName> "NT"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7be5262d417e1fddfd67eebfef74373a> <http://xmlns.com/foaf/0.1/familyName> "Malintan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-7be5262d417e1fddfd67eebfef74373a> <http://xmlns.com/foaf/0.1/name> "NT Malintan"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-990245c044c58ce77f8600013e836153> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-990245c044c58ce77f8600013e836153> <http://xmlns.com/foaf/0.1/givenName> "DB"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-990245c044c58ce77f8600013e836153> <http://xmlns.com/foaf/0.1/familyName> "Sattelle"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-990245c044c58ce77f8600013e836153> <http://xmlns.com/foaf/0.1/name> "DB Sattelle"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9fae245e54fa823f9362f698139b46d> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-d9fae245e54fa823f9362f698139b46d> <http://xmlns.com/foaf/0.1/givenName> "SD"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9fae245e54fa823f9362f698139b46d> <http://xmlns.com/foaf/0.1/familyName> "Buckingham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-d9fae245e54fa823f9362f698139b46d> <http://xmlns.com/foaf/0.1/name> "SD Buckingham"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014907> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1014907> <http://www.w3.org/2000/01/rdf-schema#label> "Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin (Text)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://purl.org/dc/elements/1.1/hasVersion> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://eprints.org/ontology/hasPublished> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014907> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10087107/1/s41598-019-53535-1.pdf> .
<https://discovery.ucl.ac.uk/id/document/1014907> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10087107/1/s41598-019-53535-1.pdf> .
<https://discovery.ucl.ac.uk/id/eprint/10087107/1/s41598-019-53535-1.pdf> <http://www.w3.org/2000/01/rdf-schema#label> "s41598-019-53535-1.pdf"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1014908> .
<https://discovery.ucl.ac.uk/id/document/1014908> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1014908> <http://www.w3.org/2000/01/rdf-schema#label> "Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1014908> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014908> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014908> <http://eprints.org/relation/islightboxThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014908> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10087107/2/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/document/1014908> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10087107/2/lightbox.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10087107/2/lightbox.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "lightbox.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1014909> .
<https://discovery.ucl.ac.uk/id/document/1014909> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1014909> <http://www.w3.org/2000/01/rdf-schema#label> "Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1014909> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014909> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014909> <http://eprints.org/relation/ispreviewThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014909> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10087107/3/preview.jpg> .
<https://discovery.ucl.ac.uk/id/document/1014909> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10087107/3/preview.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10087107/3/preview.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "preview.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1014910> .
<https://discovery.ucl.ac.uk/id/document/1014910> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1014910> <http://www.w3.org/2000/01/rdf-schema#label> "Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1014910> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014910> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014910> <http://eprints.org/relation/ismediumThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014910> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10087107/4/medium.jpg> .
<https://discovery.ucl.ac.uk/id/document/1014910> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10087107/4/medium.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10087107/4/medium.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "medium.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1014911> .
<https://discovery.ucl.ac.uk/id/document/1014911> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1014911> <http://www.w3.org/2000/01/rdf-schema#label> "Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1014911> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014911> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014911> <http://eprints.org/relation/issmallThumbnailVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014911> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10087107/5/small.jpg> .
<https://discovery.ucl.ac.uk/id/document/1014911> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10087107/5/small.jpg> .
<https://discovery.ucl.ac.uk/id/eprint/10087107/5/small.jpg> <http://www.w3.org/2000/01/rdf-schema#label> "small.jpg"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://eprints.org/ontology/hasDocument> <https://discovery.ucl.ac.uk/id/document/1014912> .
<https://discovery.ucl.ac.uk/id/document/1014912> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/Document> .
<https://discovery.ucl.ac.uk/id/document/1014912> <http://www.w3.org/2000/01/rdf-schema#label> "Calcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin (Other)"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/document/1014912> <http://eprints.org/relation/isVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014912> <http://eprints.org/relation/isVolatileVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014912> <http://eprints.org/relation/isIndexCodesVersionOf> <https://discovery.ucl.ac.uk/id/document/1014907> .
<https://discovery.ucl.ac.uk/id/document/1014912> <http://eprints.org/ontology/hasFile> <https://discovery.ucl.ac.uk/id/eprint/10087107/6/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/document/1014912> <http://purl.org/dc/terms/hasPart> <https://discovery.ucl.ac.uk/id/eprint/10087107/6/indexcodes.txt> .
<https://discovery.ucl.ac.uk/id/eprint/10087107/6/indexcodes.txt> <http://www.w3.org/2000/01/rdf-schema#label> "indexcodes.txt"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10087107> <http://www.w3.org/2000/01/rdf-schema#seeAlso> <https://discovery.ucl.ac.uk/id/eprint/10087107/> .
<https://discovery.ucl.ac.uk/id/eprint/10087107/> <http://purl.org/dc/elements/1.1/title> "HTML Summary of #10087107 \n\nCalcium signalling in mammalian cell lines expressing wild type and mutant human α1-Antitrypsin\n\n" .
<https://discovery.ucl.ac.uk/id/eprint/10087107/> <http://purl.org/dc/elements/1.1/format> "text/html" .
<https://discovery.ucl.ac.uk/id/eprint/10087107/> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10087107> .