TY  - JOUR
TI  - Aerobic oxidations in flow: opportunities for the fine chemicals and pharmaceuticals industries
AV  - public
VL  - 1
SP  - 595
Y1  - 2016/12/01/
EP  - 612
IS  - 6
N1  - This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. http://creativecommons.org/licenses/by/3.0/
N2  - Molecular oxygen is without doubt the greenest oxidant for redox reactions, yet aerobic oxidation is one of
the most challenging to perform with good chemoselectivity, particularly on an industrial scale. This collaborative review (between teams of chemists and chemical engineers) describes the current scientific and
operational hurdles that prevent the utilisation of aerobic oxidation reactions for the production of speciality chemicals and active pharmaceutical ingredients (APIs). The safety aspects of these reactions are
discussed, followed by an overview of (continuous flow) reactors suitable for aerobic oxidation reactions
that can be applied on scale. Some examples of how these reactions are currently performed in the industrial laboratory (in batch and in flow) are presented, with particular focus on the scale-up strategy. Last but
not least, further challenges and future perspectives are presented in the concluding remarks.
ID  - discovery10086977
UR  - https://doi.org/10.1039/c6re00155f
PB  - ROYAL SOC CHEMISTRY
JF  - Reaction Chemistry & Engineering
A1  - Gavriilidis, A
A1  - Constantinou, A
A1  - Hellgardt, K
A1  - (Mimi) Hii, KK
A1  - Hutchings, GJ
A1  - Brett, GL
A1  - Kuhn, S
A1  - Marsden, SP
ER  -