eprintid: 10086542
rev_number: 22
eprint_status: archive
userid: 608
dir: disk0/10/08/65/42
datestamp: 2019-11-26 12:55:06
lastmod: 2021-11-23 01:19:48
status_changed: 2019-11-26 12:55:06
type: article
metadata_visibility: show
creators_name: Jani, Y
title: Sustaining and spreading penicillin allergy de-labelling: a narrative review of the challenges for service delivery and patient safety
ispublished: pub
subjects: UCH
divisions: UCL
divisions: B02
divisions: C08
divisions: D10
divisions: G11
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Many patients report allergies to penicillin, although in over 90% of these the label of penicillin allergy is shown to be incorrect following comprehensive testing. Inappropriate and inaccurate penicillin allergy labelling is a barrier to antimicrobial stewardship and can lead to patient harm. This review assesses an emergent evidence base and trend favouring delabelling using direct oral penicillin challenges following a stratified risk assessment of the likelihood and existence of true penicillin allergy, to identify and make recommendations for key components for implementation in standard practice. Research to date has focussed on the feasibility and clinical and financial outcomes of these direct delabelling strategies. There is a paucity of studies exploring the views and engagement of patients and healthcare professionals, and a gap in the evidence for prerequisites to safely deliver, sustain and spread the implementation of such services across health systems.
date: 2020-03
date_type: published
publisher: Wiley
official_url: https://doi.org/10.1111/bcp.14190
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1722868
doi: 10.1111/bcp.14190
lyricists_name: Jani, Yogini
lyricists_id: YHJAN61
actors_name: Jani, Yogini
actors_name: Stacey, Thomas
actors_id: YHJAN61
actors_id: TSSTA20
actors_role: owner
actors_role: impersonator
full_text_status: public
publication: British Journal of Clinical Pharmacology
volume: 86
number: 3
pagerange: 548-559
citation:        Jani, Y;      (2020)    Sustaining and spreading penicillin allergy de-labelling: a narrative review of the challenges for service delivery and patient safety.                   British Journal of Clinical Pharmacology , 86  (3)   pp. 548-559.    10.1111/bcp.14190 <https://doi.org/10.1111/bcp.14190>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10086542/1/Jani%20Allergy%20delabelling_narrative%20review_finalvNov2019_full.pdf