eprintid: 10086432
rev_number: 19
eprint_status: archive
userid: 608
dir: disk0/10/08/64/32
datestamp: 2019-11-20 15:50:26
lastmod: 2022-01-24 23:30:10
status_changed: 2019-11-20 15:50:26
type: article
metadata_visibility: show
creators_name: Zartaloudi, E
creators_name: Laws, KR
creators_name: Bramon, E
title: Endophenotypes of executive functions in obsessive compulsive disorder? A meta-analysis in unaffected relatives.
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D79
divisions: D65
divisions: H20
keywords: Cognitive functioning, endophenotype, executive functioning, meta-analysis, obsessive compulsive disorder
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Endophenotypes are mediator traits between genetic influences and clinical phenotypes. Meta-analyses have consistently shown modest impairments of executive functioning in obsessive compulsive disorder (OCD) patients compared to healthy controls. Similar deficits have also been reported in unaffected relatives of OCD patients, but have not been quantified. We conducted the first meta-analysis combining all studies investigating executive functioning in unaffected relatives of individuals with OCD to quantify any deficits. A search of Pubmed, Medline and PsychInfo databases identified 21 suitable papers comprising 707 unaffected relatives of OCD patients and 842 healthy controls. Effect sizes were calculated using random effects models. Unaffected relatives displayed a significant impairment in global executive functioning. Analyses of specific executive functioning subdomains revealed impairments in: planning, visuospatial working memory and verbal fluency. Deficits in executive functioning are promising endophenotypes for OCD. To identify further biomarkers of disease risk/resilience in OCD, we suggest examining specific executive functioning domains.
date: 2019-12
date_type: published
official_url: https://doi.org/10.1097/YPG.0000000000000241
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1709347
doi: 10.1097/YPG.0000000000000241
lyricists_name: Bramon, Elvira
lyricists_name: Zartaloudi, Eirini
lyricists_id: EBRAM47
lyricists_id: EZART00
actors_name: Zahnhausen-Stuber, Petra
actors_id: PMZAH20
actors_role: owner
full_text_status: public
publication: Psychiatric Genetics
volume: 29
number: 6
pagerange: 211-219
event_location: England
issn: 1473-5873
citation:        Zartaloudi, E;    Laws, KR;    Bramon, E;      (2019)    Endophenotypes of executive functions in obsessive compulsive disorder? A meta-analysis in unaffected relatives.                   Psychiatric Genetics , 29  (6)   pp. 211-219.    10.1097/YPG.0000000000000241 <https://doi.org/10.1097/YPG.0000000000000241>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10086432/1/Zartaloudi_Endophenotypes%20of%20executive%20functions%20in%20obsessive%20compulsive%20disorder%20A%20meta%20analysis%20in%20unaffected%20relatives.pdf