eprintid: 10086432 rev_number: 19 eprint_status: archive userid: 608 dir: disk0/10/08/64/32 datestamp: 2019-11-20 15:50:26 lastmod: 2022-01-24 23:30:10 status_changed: 2019-11-20 15:50:26 type: article metadata_visibility: show creators_name: Zartaloudi, E creators_name: Laws, KR creators_name: Bramon, E title: Endophenotypes of executive functions in obsessive compulsive disorder? A meta-analysis in unaffected relatives. ispublished: pub divisions: UCL divisions: B02 divisions: C07 divisions: D79 divisions: D65 divisions: H20 keywords: Cognitive functioning, endophenotype, executive functioning, meta-analysis, obsessive compulsive disorder note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: Endophenotypes are mediator traits between genetic influences and clinical phenotypes. Meta-analyses have consistently shown modest impairments of executive functioning in obsessive compulsive disorder (OCD) patients compared to healthy controls. Similar deficits have also been reported in unaffected relatives of OCD patients, but have not been quantified. We conducted the first meta-analysis combining all studies investigating executive functioning in unaffected relatives of individuals with OCD to quantify any deficits. A search of Pubmed, Medline and PsychInfo databases identified 21 suitable papers comprising 707 unaffected relatives of OCD patients and 842 healthy controls. Effect sizes were calculated using random effects models. Unaffected relatives displayed a significant impairment in global executive functioning. Analyses of specific executive functioning subdomains revealed impairments in: planning, visuospatial working memory and verbal fluency. Deficits in executive functioning are promising endophenotypes for OCD. To identify further biomarkers of disease risk/resilience in OCD, we suggest examining specific executive functioning domains. date: 2019-12 date_type: published official_url: https://doi.org/10.1097/YPG.0000000000000241 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1709347 doi: 10.1097/YPG.0000000000000241 lyricists_name: Bramon, Elvira lyricists_name: Zartaloudi, Eirini lyricists_id: EBRAM47 lyricists_id: EZART00 actors_name: Zahnhausen-Stuber, Petra actors_id: PMZAH20 actors_role: owner full_text_status: public publication: Psychiatric Genetics volume: 29 number: 6 pagerange: 211-219 event_location: England issn: 1473-5873 citation: Zartaloudi, E; Laws, KR; Bramon, E; (2019) Endophenotypes of executive functions in obsessive compulsive disorder? A meta-analysis in unaffected relatives. Psychiatric Genetics , 29 (6) pp. 211-219. 10.1097/YPG.0000000000000241 <https://doi.org/10.1097/YPG.0000000000000241>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10086432/1/Zartaloudi_Endophenotypes%20of%20executive%20functions%20in%20obsessive%20compulsive%20disorder%20A%20meta%20analysis%20in%20unaffected%20relatives.pdf