TY - JOUR AV - public JF - Nature Sustainability EP - 71 N1 - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions. ID - discovery10086408 VL - 3 A1 - Varah, A A1 - Ahodo, K A1 - Coutts, S A1 - Hicks, H A1 - Comont, D A1 - Crook, L A1 - Hull, R A1 - Neve, P A1 - Childs, D A1 - Freckleton, P A1 - Norris, K Y1 - 2020/01// N2 - Pesticides have underpinned significant improvements in global food security, albeit with associated environmental costs. Currently, the yield benefits of pesticides are threatened as overuse has led to wide-scale evolution of resistance. Despite this threat, there are no large-scale estimates of crop yield losses or economic costs due to resistance. Here, we combine national-scale density and resistance data for the weed Alopecurus myosuroides (black-grass) with crop yield maps and an economic model to estimate resistance impacts. We estimate that the annual cost of resistance in England is £0.4 billion in lost gross profit (2014 prices) and annual wheat yield loss due to resistance is 0.8 million tonnes. A total loss of herbicide control against black-grass would cost £1 billion and 3.4 million tonnes of lost wheat yield annually. Worldwide, there are 253 herbicide-resistant weeds, so the global impact of resistance could be enormous. Our research supports urgent national-scale planning to combat resistance and an incentive for increasing yields through food-production systems rather than herbicides. TI - The costs of human-induced evolution in an agricultural system SP - 63 UR - https://doi.org/10.1038/s41893-019-0450-8 ER -