eprintid: 10086245
rev_number: 18
eprint_status: archive
userid: 608
dir: disk0/10/08/62/45
datestamp: 2019-11-20 10:30:21
lastmod: 2021-10-04 01:14:36
status_changed: 2019-11-20 10:30:21
type: article
metadata_visibility: show
creators_name: Ibáñez, J
creators_name: Spampinato, DA
creators_name: Paraneetharan, V
creators_name: Rothwell, JC
title: SICI during changing brain states: Differences in methodology can lead to different conclusions
ispublished: inpress
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Transcranial magnetic stimulation, Short intra-cortical inhibition, Movement preparation, Preparatory inhibitio
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abstract: Background: Short-latency intracortical inhibition (SICI) is extensively used to probe GABAergic inhibitory mechanisms in M1. Task-related changes in SICI are presumed to reflect changes in the central
excitability of GABAergic pathways. Usually, the level of SICI is evaluated using a single intensity of
conditioning stimulus so that inhibition can be compared in different brain states.
Objective: Here, we show that this approach may sometimes be inadequate since distinct conclusions
can be drawn if a different CS intensity is used.
Methods: We measured SICI using a range of CS intensities at rest and during a warned simple reaction
time task.
Conclusions: Our results show that SICI changes that occurred during the task could be either larger or
smaller than at rest depending on the intensity of the CS. These findings indicate that careful interpretation of results are needed when a single intensity of CS is used to measure task-related physiological
changes.
date: 2019-11-04
date_type: published
official_url: https://doi.org/10.1016/j.brs.2019.11.002
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1719802
doi: 10.1016/j.brs.2019.11.002
pii: S1935-861X(19)30433-4
lyricists_name: Ibanez Pereda, Jaime
lyricists_name: Rothwell, John
lyricists_name: Spampinato, Danny
lyricists_id: JIBAN30
lyricists_id: JCROT52
lyricists_id: DSPAM75
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Brain Stimulation
event_location: United States
citation:        Ibáñez, J;    Spampinato, DA;    Paraneetharan, V;    Rothwell, JC;      (2019)    SICI during changing brain states: Differences in methodology can lead to different conclusions.                   Brain Stimulation        10.1016/j.brs.2019.11.002 <https://doi.org/10.1016/j.brs.2019.11.002>.    (In press).    Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10086245/1/1-s2.0-S1935861X19304334-main.pdf