eprintid: 10086007 rev_number: 25 eprint_status: archive userid: 608 dir: disk0/10/08/60/07 datestamp: 2019-11-15 14:33:12 lastmod: 2021-10-05 00:34:35 status_changed: 2019-11-15 14:33:12 type: article metadata_visibility: show creators_name: Spampinato, D creators_name: Ibáñez, J creators_name: Spanoudakis, M creators_name: Hammond, P creators_name: Rothwell, JC title: Cerebellar transcranial magnetic stimulation: The role of coil type from distinct manufacturers ispublished: inpress divisions: UCL divisions: B02 divisions: C07 divisions: D07 divisions: F84 keywords: Cerebellar-M1, Cerebellum, Connectivity, Transcranial magnetic stimulation note: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. abstract: BACKGROUND: Stimulating the cerebellum with transcranial magnetic stimulation is often perceived as uncomfortable. No study has systematically tested which coil design can effectively trigger a cerebellar response with the least discomfort. OBJECTIVE: To determine the relationship between perceived discomfort and effectiveness of cerebellar stimulation using different coils: MagStim (70 mm, 110 mm-coated, 110-uncoated), MagVenture and Deymed. METHODS: Using the cerebellar-brain inhibition (CBI) protocol, we conducted a CBI recruitment curve with respect to each participant's maximum tolerated-stimulus intensity (MTI) to assess how effective each coil was at activating the cerebellum. RESULTS: Only the Deymed double-cone coil elicited CBI at low intensities (-20% MTI). At the MTI, the MagStim (110 mm coated/uncoated) and Deymed coils produced reliable CBI, whereas no CBI was found with the MagVenture coil. CONCLUSION: s: The Deymed double-cone coil was most effective at cerebellar stimulation at tolerable intensities. These results can guide coil selection and stimulation parameters when designing cerebellar TMS studies. date: 2019-10-12 date_type: published official_url: https://doi.org/10.1016/j.brs.2019.09.005 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1714116 doi: 10.1016/j.brs.2019.09.005 pii: S1935-861X(19)30368-7 lyricists_name: Hammond, Paul lyricists_name: Ibanez Pereda, Jaime lyricists_name: Rothwell, John lyricists_name: Spampinato, Danny lyricists_id: PCHAM66 lyricists_id: JIBAN30 lyricists_id: JCROT52 lyricists_id: DSPAM75 actors_name: Jayawardana, Anusha actors_id: AJAYA51 actors_role: owner full_text_status: public publication: Brain Stimulation event_location: United States issn: 1876-4754 citation: Spampinato, D; Ibáñez, J; Spanoudakis, M; Hammond, P; Rothwell, JC; (2019) Cerebellar transcranial magnetic stimulation: The role of coil type from distinct manufacturers. Brain Stimulation 10.1016/j.brs.2019.09.005 <https://doi.org/10.1016/j.brs.2019.09.005>. (In press). Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10086007/1/Rothwell_cbi_coils_manu2_ds.pdf