eprintid: 10085690 rev_number: 23 eprint_status: archive userid: 608 dir: disk0/10/08/56/90 datestamp: 2019-11-12 11:36:58 lastmod: 2021-09-26 22:49:46 status_changed: 2019-11-12 11:36:58 type: article metadata_visibility: show creators_name: Ku, P-W creators_name: Hamer, M creators_name: Liao, Y creators_name: Hsueh, M-C creators_name: Chen, L-J title: Device-measured light-intensity physical activity and mortality: A meta-analysis ispublished: pub divisions: UCL divisions: B02 divisions: C10 divisions: D16 keywords: guideline, LIPA, meta-regression, recommendation, review note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. abstract: INTRODUCTION: The association of light‐intensity physical activity (LPA) with mortality is poorly understood. This meta‐analysis of cohort studies aimed to examine the dose‐response relationships between daily device‐measured LPA and mortality in adults aged 18 or older and to explore whether the associations were independent of moderate‐to‐vigorous physical activity (MVPA). METHODS: Searches for prospective cohort studies providing effect estimates of daily LPA (exposure) on all‐cause mortality (outcome) were systematically undertaken in electronic databases up to April 30, 2019. Subgroup analyses and meta‐regression analyses with random‐effects models were performed to quantify the dose‐response relationships between daily LPA and mortality. Sensitivity analyses were also conducted to assess the stability of the results. RESULTS: A total of 11 studies were included in the meta‐analysis. Analyses contained 49 239 individuals (mean age 60.7, SD = 13.6) who were followed up for a mean 6.2 years (2.3‐14.2 years), during which 3669 (7.5%) died. In comparison with the reference group (<3 h/d), the pooled HRs (and 95% CIs) of mortality were 0.71 (0.62‐0.82), 0.68 (0.59‐0.79), 0.56 (0.44‐0.71) for groups 3 to <5 h/d, 5 to <7 h/d, and more than 7 hours a day LPA, respectively. Meta‐regression models indicated that there was a log‐cubic dose‐response relationship between daily LPA and mortality in adults and older people, independent of MVPA. CONCLUSIONS: Time spent in daily LPA was associated with reduced risks of mortality in adults and older people. These data support the inclusion of LPA in the future physical activity guidelines. date: 2020-01 date_type: published publisher: WILEY official_url: https://doi.org/10.1111/sms.13557 oa_status: green full_text_type: other language: eng primo: open primo_central: open_green verified: verified_manual elements_id: 1717941 doi: 10.1111/sms.13557 lyricists_name: Hamer, Mark lyricists_id: MHAME21 actors_name: Hamer, Mark actors_id: MHAME21 actors_role: owner full_text_status: public publication: Scandinavian Journal of Medicine & Science in Sports volume: 30 number: 1 pagerange: 13-24 pages: 12 issn: 1600-0838 citation: Ku, P-W; Hamer, M; Liao, Y; Hsueh, M-C; Chen, L-J; (2020) Device-measured light-intensity physical activity and mortality: A meta-analysis. Scandinavian Journal of Medicine & Science in Sports , 30 (1) pp. 13-24. 10.1111/sms.13557 <https://doi.org/10.1111/sms.13557>. Green open access document_url: https://discovery.ucl.ac.uk/id/eprint/10085690/2/Hamer_Device-measured%20light-intensity%20physical%20activity%20and%20mortality_AAM.pdf