eprintid: 10085153
rev_number: 16
eprint_status: archive
userid: 608
dir: disk0/10/08/51/53
datestamp: 2019-11-14 16:29:57
lastmod: 2021-09-17 22:16:08
status_changed: 2019-11-14 16:29:57
type: article
metadata_visibility: show
creators_name: Mainka, T
creators_name: Balint, B
creators_name: Gövert, F
creators_name: Kurvits, L
creators_name: van Riesen, C
creators_name: Kühn, AA
creators_name: Tijssen, MAJ
creators_name: Lees, AJ
creators_name: Müller-Vahl, K
creators_name: Bhatia, KP
creators_name: Ganos, C
title: The spectrum of involuntary vocalizations in humans: A video atlas
ispublished: pub
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Involuntary vocalizations, movement disorders, vocalizing behavior
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abstract: In clinical practice, involuntary vocalizing behaviors are typically associated with Tourette syndrome and other tic disorders. However, they may also be encountered throughout the entire tenor of neuropsychiatry, movement disorders, and neurodevelopmental syndromes. Importantly, involuntary vocalizing behaviors may often constitute a predominant clinical sign, and, therefore, their early recognition and appropriate classification are necessary to guide diagnosis and treatment. Clinical literature and video‐documented cases on the topic are surprisingly scarce. Here, we pooled data from 5 expert centers of movement disorders, with instructive video material to cover the entire range of involuntary vocalizations in humans. Medical literature was also reviewed to document the range of possible etiologies associated with the different types of vocalizing behaviors and to explore treatment options. We propose a phenomenological classification of involuntary vocalizations within different categorical domains, including (1) tics and tic‐like vocalizations, (2) vocalizations as part of stereotypies, (3) vocalizations as part of dystonia or chorea, (4) continuous vocalizing behaviors such as groaning or grunting, (5) pathological laughter and crying, (6) vocalizations resembling physiological reflexes, and (7) other vocalizations, for example, those associated with exaggerated startle responses, as part of epilepsy and sleep‐related phenomena. We provide comprehensive lists of their associated etiologies, including neurodevelopmental, neurodegenerative, neuroimmunological, and structural causes and clinical clues. We then expand on the pathophysiology of the different vocalizing behaviors and comment on available treatment options. Finally, we present an algorithmic approach that covers the wide range of involuntary vocalizations in humans, with the ultimate goal of improving diagnostic accuracy and guiding appropriate treatment.
date: 2019-10-25
date_type: published
official_url: https://doi.org/10.1002/mds.27855
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1714124
doi: 10.1002/mds.27855
lyricists_name: Bhatia, Kailash
lyricists_name: Lees, Andrew
lyricists_id: KPBHA96
lyricists_id: AJLEE60
actors_name: Kalinowski, Damian
actors_id: DKALI47
actors_role: owner
full_text_status: public
publication: Movement Disorders
event_location: United States
citation:        Mainka, T;    Balint, B;    Gövert, F;    Kurvits, L;    van Riesen, C;    Kühn, AA;    Tijssen, MAJ;                 ... Ganos, C; + view all <#>        Mainka, T;  Balint, B;  Gövert, F;  Kurvits, L;  van Riesen, C;  Kühn, AA;  Tijssen, MAJ;  Lees, AJ;  Müller-Vahl, K;  Bhatia, KP;  Ganos, C;   - view fewer <#>    (2019)    The spectrum of involuntary vocalizations in humans: A video atlas.                   Movement Disorders        10.1002/mds.27855 <https://doi.org/10.1002/mds.27855>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10085153/1/Bhatia_The%20spectrum%20of%20involuntary%20vocalizations%20in%20humans.%20A%20video%20atlas_AOP.pdf