TY  - INPR
AV  - public
ID  - discovery10085103
SN  - 1535-4970
KW  - Colonisation
KW  -  Human infection model
KW  -  Streptococcus pneumoniae
KW  -  alveolar macrophages
A1  - Brown, JS
N2  - Streptococcus pneumoniae is a common cause of bacterial pneumonia especially in
the elderly or those with significant comorbidities, and is also frequently associated
with exacerbations of COPD (1, 2). Existing S. pneumoniae vaccines have partial
strain coverage, may lack efficacy in high risk groups, and generally seem to have
poorer efficacy against pulmonary compared to systemic infection (3,4). Hence
alternative strategies to conventional vaccines maybe required to prevent the
persisting high morbidity and mortality caused by S. pneumoniae lung infections.
UR  - https://doi.org/10.1164/rccm.201910-2047ED
Y1  - 2019/10/30/
JF  - American Journal of Respiratory and Critical Care Medicine
N1  - This version is the author accepted manuscript. For information on re-use, please refer to the publisher?s terms and conditions.
TI  - Improving Pulmonary Immunity to Bacterial Pathogens Through Streptococcus pneumoniae Colonisation of the Nasopharynx
ER  -