<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10084993> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/title> "Early treatment with ambrisentan of mildly elevated mean pulmonary arterial pressure associated with systemic sclerosis: a randomized, controlled, double-blind, parallel group study (EDITA study)"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/abstract> "OBJECTIVE: The objective of this randomized, placebo-controlled, double-blind, parallel group, trial was to assess the effect of ambrisentan on mean pulmonary arterial pressure (mPAP) in patients with systemic sclerosis (SSc) and mildly elevated pulmonary hypertension (PH). METHODS: Thirty-eight SSc patients with mildly elevated mPAP at rest between 21 and 24 mmHg and/or > 30 mmHg during low-dose exercise were randomly assigned to treatment with either ambrisentan 5-10 mg/day or placebo. Right heart catheterization and further clinical parameters were assessed at baseline and after 6 months. The primary endpoint was the difference of mPAP change at rest between groups. RESULTS: After 6 months, the two groups did not differ in the primary endpoint (ambrisentan mPAP - 1 ± 6.4 mmHg vs. placebo - 0.73 ± 3.59 mmHg at rest, p = 0.884). However, three patients from the placebo group but none of the ambrisentan group progressed to SSc-associated pulmonary arterial hypertension. Furthermore, ambrisentan treatment showed significant improvements in the secondary endpoints cardiac index (CI) and pulmonary vascular resistance (PVR) at rest (CI 0.36 ± 0.66 l/min/m2 vs. - 0.31 ± 0.71 l/min/m2, p = 0.010; PVR - 0.70 ± 0.78 WU vs. 0.01 ± 0.71 WU, p = 0.012) and during exercise (CI 0.7 ± 0.81 l/min/m2 vs. - 0.45 ± 1.36 l/min/m2, p = 0.015; PVR - 0.84 ± 0.48 WU vs. - 0.0032 ± 0.34 WU, p < 0.0001). CONCLUSION: This is the first randomized, double-blind, placebo-controlled study testing the effect of ambrisentan in patients with mildly elevated mPAP and/or exercise PH. The primary endpoint change in mPAP did only tendentially improve in the ambrisentan group, but the significant improvement of other hemodynamic parameters points to a possible benefit of ambrisentan and will be helpful to design future trials. TRIAL REGISTRATION: www.ClinicalTrials.gov, unique identifier NCT: NCT02290613 , registered 14th of November 2014."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/date> "2019-10-26" . <https://discovery.ucl.ac.uk/id/document/1001033> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/volume> "21" . <https://discovery.ucl.ac.uk/id/publication/ext-14786362> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-14786362> <http://xmlns.com/foaf/0.1/name> "Arthritis Research and Therapy"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/publication/ext-14786362> . 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<https://discovery.ucl.ac.uk/id/person/ext-1823d5182972a45245a67266c9f297b1> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-1823d5182972a45245a67266c9f297b1> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-e367985afeb2271e431d66f96f2fba77> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-e367985afeb2271e431d66f96f2fba77> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-18cd2ad7323839fccdaaf9d28fb9272f> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-18cd2ad7323839fccdaaf9d28fb9272f> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-cacafb6aae915664f8738f20f0029581> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-cacafb6aae915664f8738f20f0029581> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-a9151dbdae9c0ac017da17e081132dfa> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-a9151dbdae9c0ac017da17e081132dfa> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-92fdb121b9f1a607f8d5865dd15fd01e> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_13> <https://discovery.ucl.ac.uk/id/person/ext-92fdb121b9f1a607f8d5865dd15fd01e> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-0a7817d47a546ee9e86cb366d0b156ae> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_14> <https://discovery.ucl.ac.uk/id/person/ext-0a7817d47a546ee9e86cb366d0b156ae> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-bc4f65c391096c6affd7651ea5bcdfa9> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_15> <https://discovery.ucl.ac.uk/id/person/ext-bc4f65c391096c6affd7651ea5bcdfa9> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3b2ee572c2b279845812df32c4a058fc> . <https://discovery.ucl.ac.uk/id/eprint/10084993> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> . <https://discovery.ucl.ac.uk/id/eprint/10084993#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_16> <https://discovery.ucl.ac.uk/id/person/ext-3b2ee572c2b279845812df32c4a058fc> . <https://discovery.ucl.ac.uk/id/person/ext-e367985afeb2271e431d66f96f2fba77> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-e367985afeb2271e431d66f96f2fba77> <http://xmlns.com/foaf/0.1/givenName> "CP"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e367985afeb2271e431d66f96f2fba77> <http://xmlns.com/foaf/0.1/familyName> "Denton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-e367985afeb2271e431d66f96f2fba77> <http://xmlns.com/foaf/0.1/name> "CP Denton"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc4f65c391096c6affd7651ea5bcdfa9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-bc4f65c391096c6affd7651ea5bcdfa9> <http://xmlns.com/foaf/0.1/givenName> "H-M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc4f65c391096c6affd7651ea5bcdfa9> <http://xmlns.com/foaf/0.1/familyName> "Lorenz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-bc4f65c391096c6affd7651ea5bcdfa9> <http://xmlns.com/foaf/0.1/name> "H-M Lorenz"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9cdc27135367175a081e1f3e2bd07e32> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9cdc27135367175a081e1f3e2bd07e32> 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