@article{discovery10084889, month = {November}, pages = {1534--1540}, journal = {Multiple Sclerosis Journal}, note = {This article is distributed under the terms of the Creative Commons Attribution-Non Commercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).}, publisher = {SAGE PUBLICATIONS LTD}, year = {2012}, volume = {18}, number = {11}, title = {Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS}, url = {https://doi.org/10.1177/1352458512458169}, author = {Fox, RJ and Thompson, A and Baker, D and Baneke, P and Brown, D and Browne, P and Chandraratna, D and Ciccarelli, O and Coetzee, T and Comi, G and Feinstein, A and Kapoor, R and Lee, K and Salvetti, M and Sharrock, K and Toosy, A and Zaratin, P and Zuidwijk, K}, abstract = {Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify key priority areas for research. A collaborative was convened by volunteer and staff leaders from several MS societies with the mission to expedite the development of effective disease-modifying and symptom management therapies for progressive forms of multiple sclerosis. Through a series of scientific and strategic planning meetings, the collaborative identified and developed new perspectives on five key priority areas for research: experimental models, identification and validation of targets and repurposing opportunities, proof-of-concept clinical trial strategies, clinical outcome measures, and symptom management and rehabilitation. Our conclusions, tackling the impediments in developing therapies for progressive MS will require an integrated, multi-disciplinary approach to enable effective translation of research into therapies for progressive MS. Engagement of the MS research community through an international effort is needed to address and fund these research priorities with the ultimate goal of expediting the development of disease-modifying and symptom-relief treatments for progressive MS.}, keywords = {multiple sclerosis, progressive multiple sclerosis, neuroprotection, rehabilitation, research agenda} }