TY  - INPR
N1  - © 2019, Cornford et al. This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
TI  - Dendritic NMDA receptors in parvalbumin neurons enable strong and stable neuronal assemblies
AV  - public
Y1  - 2019/10/28/
VL  - 8
JF  - eLife
A1  - Cornford, JH
A1  - Mercier, MS
A1  - Leite, M
A1  - Magloire, V
A1  - Häusser, M
A1  - Kullmann, DM
N2  - Parvalbumin-expressing (PV+) GABAergic interneurons mediate feedforward and feedback inhibition and have a key role in gamma oscillations and information processing. The importance of fast synaptic recruitment, action potential initiation and repolarization, and rapid synchronous GABA release by PV+ cells is well established. In contrast, the functional significance of PV+ cell NMDA receptors (NMDARs), which generate relatively slow postsynaptic currents, is unclear. Underlining their importance, several studies implicate PV+ cell NMDAR disruption in impaired network function and circuit pathologies. Here, we show that dendritic NMDARs underlie supralinear integration of feedback excitation from local pyramidal neurons onto mouse CA1 PV+ cells. Furthermore, by incorporating NMDARs at feedback connections onto PV+ cells in spiking networks, we show that these receptors enable cooperative recruitment of PV+ interneurons, strengthening and stabilising principal cell assemblies. Failure of this phenomenon provides a parsimonious explanation for cognitive and sensory gating deficits in pathologies with impaired PV+ NMDAR signalling.
ID  - discovery10084606
PB  - eLife Sciences Publications, Ltd
UR  - https://doi.org/10.7554/elife.49872
SN  - 2050-084X
ER  -