<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> .
<> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10084591> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/title> "Salt and Water Retention Is Associated with Microinflammation and Endothelial Injury in Chronic Kidney Disease"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: Progressive chronic kidney disease (CKD) inevitably leads to salt and water retention and disturbances in the macro-and microcirculation. OBJECTIVES: We hypothesize that salt and water dysregulation in advanced CKD may be linked to inflammation and microvascular injury pathways. METHODS: We studied 23 CKD stage 5 patients and 11 healthy controls (HC). Tissue sodium concentration was assessed using 23Sodium magnetic resonance (MR) imaging. Hydration status was evaluated using bioimpedance spectroscopy. A panel of inflammatory and endothelial biomarkers was also measured. RESULTS: CKD patients had fluid overload (FO) when compared to HC (overhydration index: CKD = 0.5 ± 1.9 L vs. HC = -0.5 ± 1.0 L; p = 0.03). MR-derived tissue sodium concentrations were predominantly higher in the subcutaneous (SC) compartment (median [interquartile range] CKD = 22.4 mmol/L [19.4-31.3] vs. HC = 18.4 mmol/L [16.6-21.3]; p = 0.03), but not the muscle (CKD = 24.9 ± 5.5 mmol/L vs. HC = 22.8 ± 2.5 mmol/L; p = 0.26). Tissue sodium in both compartments correlated to FO (muscle: r = 0.63, p < 0.01; SC: rs = 0.63, p < 0.01). CKD subjects had elevated levels of vascular cell adhesion molecule (p < 0.05), tumor necrosis factor-alpha (p < 0.01), and interleukin (IL)-6 (p = 0.01) and lower levels of vascular endothelial growth factor-C (p = 0.04). FO in CKD was linked to higher IL-8 (r = 0.51, p < 0.05) and inversely associated to E-selectin (r = -0.52, p = 0.01). Higher SC sodium was linked to higher intracellular adhesion molecule (ICAM; rs = 0.54, p = 0.02). CONCLUSION: Salt and water accumulation in CKD appears to be linked with inflammation and endothelial activation pathways. Specifically IL-8, E-Selectin (in FO), and ICAM (in salt accumulation) may be implicated in the pathophysiology of FO and merit further investigation."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/date> "2019-12" .
<https://discovery.ucl.ac.uk/id/document/994460> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/volume> "143" .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/issue> "4" .
<https://discovery.ucl.ac.uk/id/publication/ext-22353186> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> .
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<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_4> <https://discovery.ucl.ac.uk/id/person/ext-e8f5a95641ea1446098a57371f8546d9> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-56a52e080b9af22333c3565e2b96af4b> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_5> <https://discovery.ucl.ac.uk/id/person/ext-56a52e080b9af22333c3565e2b96af4b> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-1b83d1e5bb4a03a1473686f3b9a687cc> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_6> <https://discovery.ucl.ac.uk/id/person/ext-1b83d1e5bb4a03a1473686f3b9a687cc> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-b7b190366efb844bae8aa845a7824c4b> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_7> <https://discovery.ucl.ac.uk/id/person/ext-b7b190366efb844bae8aa845a7824c4b> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-82d484821a1725cd2c02ead50cee8148> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_8> <https://discovery.ucl.ac.uk/id/person/ext-82d484821a1725cd2c02ead50cee8148> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-04f59f80d43448469fd03fbc29102b69> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_9> <https://discovery.ucl.ac.uk/id/person/ext-04f59f80d43448469fd03fbc29102b69> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-49b45e8a58d6f9d9fe2825434787ca29> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_10> <https://discovery.ucl.ac.uk/id/person/ext-49b45e8a58d6f9d9fe2825434787ca29> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-3bc9a8c5a958e9dc76be53248d627f55> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_11> <https://discovery.ucl.ac.uk/id/person/ext-3bc9a8c5a958e9dc76be53248d627f55> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/dc/terms/creator> <https://discovery.ucl.ac.uk/id/person/ext-6d1b0145d0a47239e7adff7e24aaf054> .
<https://discovery.ucl.ac.uk/id/eprint/10084591> <http://purl.org/ontology/bibo/authorList> <https://discovery.ucl.ac.uk/id/eprint/10084591#authors> .
<https://discovery.ucl.ac.uk/id/eprint/10084591#authors> <http://www.w3.org/1999/02/22-rdf-syntax-ns#_12> <https://discovery.ucl.ac.uk/id/person/ext-6d1b0145d0a47239e7adff7e24aaf054> .
<https://discovery.ucl.ac.uk/id/person/ext-1b83d1e5bb4a03a1473686f3b9a687cc> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1b83d1e5bb4a03a1473686f3b9a687cc> <http://xmlns.com/foaf/0.1/givenName> "J"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b83d1e5bb4a03a1473686f3b9a687cc> <http://xmlns.com/foaf/0.1/familyName> "Alderdice"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1b83d1e5bb4a03a1473686f3b9a687cc> <http://xmlns.com/foaf/0.1/name> "J Alderdice"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c3cf2639d21d41d0d6d3198ccaa30a4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-1c3cf2639d21d41d0d6d3198ccaa30a4> <http://xmlns.com/foaf/0.1/givenName> "D"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c3cf2639d21d41d0d6d3198ccaa30a4> <http://xmlns.com/foaf/0.1/familyName> "Mc Hough"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-1c3cf2639d21d41d0d6d3198ccaa30a4> <http://xmlns.com/foaf/0.1/name> "D Mc Hough"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e8f5a95641ea1446098a57371f8546d9> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-e8f5a95641ea1446098a57371f8546d9> <http://xmlns.com/foaf/0.1/givenName> "L"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e8f5a95641ea1446098a57371f8546d9> <http://xmlns.com/foaf/0.1/familyName> "Shalamanova"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-e8f5a95641ea1446098a57371f8546d9> <http://xmlns.com/foaf/0.1/name> "L Shalamanova"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b7b190366efb844bae8aa845a7824c4b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-b7b190366efb844bae8aa845a7824c4b> <http://xmlns.com/foaf/0.1/givenName> "R"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b7b190366efb844bae8aa845a7824c4b> <http://xmlns.com/foaf/0.1/familyName> "Mitra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-b7b190366efb844bae8aa845a7824c4b> <http://xmlns.com/foaf/0.1/name> "R Mitra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cdd8c3fde0d664e404db59746307f42> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-4cdd8c3fde0d664e404db59746307f42> <http://xmlns.com/foaf/0.1/givenName> "FMS"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cdd8c3fde0d664e404db59746307f42> <http://xmlns.com/foaf/0.1/familyName> "Alsehli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-4cdd8c3fde0d664e404db59746307f42> <http://xmlns.com/foaf/0.1/name> "FMS Alsehli"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82d484821a1725cd2c02ead50cee8148> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-82d484821a1725cd2c02ead50cee8148> <http://xmlns.com/foaf/0.1/givenName> "A"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82d484821a1725cd2c02ead50cee8148> <http://xmlns.com/foaf/0.1/familyName> "Swiecicka"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-82d484821a1725cd2c02ead50cee8148> <http://xmlns.com/foaf/0.1/name> "A Swiecicka"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-49b45e8a58d6f9d9fe2825434787ca29> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-49b45e8a58d6f9d9fe2825434787ca29> <http://xmlns.com/foaf/0.1/givenName> "GJM"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-49b45e8a58d6f9d9fe2825434787ca29> <http://xmlns.com/foaf/0.1/familyName> "Parker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-49b45e8a58d6f9d9fe2825434787ca29> <http://xmlns.com/foaf/0.1/name> "GJM Parker"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-04f59f80d43448469fd03fbc29102b69> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-04f59f80d43448469fd03fbc29102b69> <http://xmlns.com/foaf/0.1/givenName> "P"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-04f59f80d43448469fd03fbc29102b69> <http://xmlns.com/foaf/0.1/familyName> "Brenchley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-04f59f80d43448469fd03fbc29102b69> <http://xmlns.com/foaf/0.1/name> "P Brenchley"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6d1b0145d0a47239e7adff7e24aaf054> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-6d1b0145d0a47239e7adff7e24aaf054> <http://xmlns.com/foaf/0.1/givenName> "S"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6d1b0145d0a47239e7adff7e24aaf054> <http://xmlns.com/foaf/0.1/familyName> "Mitra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-6d1b0145d0a47239e7adff7e24aaf054> <http://xmlns.com/foaf/0.1/name> "S Mitra"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56a52e080b9af22333c3565e2b96af4b> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-56a52e080b9af22333c3565e2b96af4b> <http://xmlns.com/foaf/0.1/givenName> "F"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56a52e080b9af22333c3565e2b96af4b> <http://xmlns.com/foaf/0.1/familyName> "Wilkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-56a52e080b9af22333c3565e2b96af4b> <http://xmlns.com/foaf/0.1/name> "F Wilkinson"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a9317163ce202e79a7dc09777f33cb> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a9317163ce202e79a7dc09777f33cb> <http://xmlns.com/foaf/0.1/givenName> "N"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a9317163ce202e79a7dc09777f33cb> <http://xmlns.com/foaf/0.1/familyName> "Mitsides"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-c1a9317163ce202e79a7dc09777f33cb> <http://xmlns.com/foaf/0.1/name> "N Mitsides"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bc9a8c5a958e9dc76be53248d627f55> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> .
<https://discovery.ucl.ac.uk/id/person/ext-3bc9a8c5a958e9dc76be53248d627f55> <http://xmlns.com/foaf/0.1/givenName> "MY"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/person/ext-3bc9a8c5a958e9dc76be53248d627f55> <http://xmlns.com/foaf/0.1/familyName> "Alexander"^^<http://www.w3.org/2001/XMLSchema#string> .
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