eprintid: 10083685
rev_number: 25
eprint_status: archive
userid: 608
dir: disk0/10/08/36/85
datestamp: 2019-10-18 12:17:54
lastmod: 2021-10-28 22:42:08
status_changed: 2019-10-18 12:17:54
type: article
metadata_visibility: show
creators_name: Wilson, P
creators_name: Gurusamy, KS
creators_name: Morley, R
creators_name: Whiting, C
creators_name: Maeso, B
creators_name: FitzGerald, G
creators_name: Bennett, S
creators_name: Bostock, J
creators_name: Brealey, D
creators_name: Cann, M
creators_name: Kiernan, M
creators_name: Leaper, D
creators_name: Moore, M
creators_name: Oppenheim, B
creators_name: Thompson, P
creators_name: Tingle, A
title: Top research priorities in healthcare-associated infection in the UK
ispublished: pub
subjects: UCH
divisions: UCL
divisions: B02
divisions: C10
divisions: D17
divisions: D16
divisions: G85
keywords: Antibiotic resistance, Antimicrobial resistance, Healthcare-associated infections, Point-of-care testing, Research priorities
note: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
abstract: Background: There is a mismatch between research questions which are considered to be important by patients, carers and healthcare professionals and the research performed in many fields of medicine. No relevant studies which have assessed research priorities in healthcare-associated infection (HCAI) that have involved patients' and carers' opinions were identified in the literature. /

Aim: The Healthcare-Associated Infections Priority Setting Partnership was established to identify the top research priorities in the prevention, diagnosis and treatment of HCAI in the UK, considering the opinions of all these groups. /

Methods: The methods broadly followed the principles of the James Lind Alliance (JLA) priority setting activity. /

Findings: In total, 259 unique valid research questions were identified from 221 valid responses to a consultation of patients, carers and healthcare professionals after seeking their opinions for research priorities. The steering committee of the priority setting partnership rationalized these to 50 unique questions. A literature review established that for these questions there were no recent high-quality systematic reviews, high-quality systematic reviews which concluded that further studies were necessary, or the steering committee considered that further research was required despite the conclusions of recent systematic reviews. An interim survey ranked the 50 questions, and the 10 main research priorities were identified from the top 32 questions by consensus at a final priority setting workshop of patients, carers and healthcare professionals using group discussions. /

Conclusions: A priority setting process using JLA methods and principles involving patients, carers and healthcare professionals was used to identify the top 10 priority areas for research related to HCAI. Basic, translational, clinical and public health research would be required to address these uncertainties.
date: 2019-12
date_type: published
official_url: https://doi.org/10.1016/j.jhin.2019.08.013
oa_status: green
full_text_type: other
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1684397
doi: 10.1016/j.jhin.2019.08.013
pii: S0195-6701(19)30325-1
lyricists_name: Brealey, David
lyricists_name: Gurusamy, Kurinchi
lyricists_id: DABRE93
lyricists_id: GURUS55
actors_name: Austen, Jennifer
actors_id: JAUST66
actors_role: owner
full_text_status: public
publication: Journal of Hospital Infection
volume: 103
number: 4
pagerange: 382-287
event_location: England
issn: 1532-2939
citation:        Wilson, P;    Gurusamy, KS;    Morley, R;    Whiting, C;    Maeso, B;    FitzGerald, G;    Bennett, S;                                     ... Tingle, A; + view all <#>        Wilson, P;  Gurusamy, KS;  Morley, R;  Whiting, C;  Maeso, B;  FitzGerald, G;  Bennett, S;  Bostock, J;  Brealey, D;  Cann, M;  Kiernan, M;  Leaper, D;  Moore, M;  Oppenheim, B;  Thompson, P;  Tingle, A;   - view fewer <#>    (2019)    Top research priorities in healthcare-associated infection in the UK.                   Journal of Hospital Infection , 103  (4)   pp. 382-287.    10.1016/j.jhin.2019.08.013 <https://doi.org/10.1016/j.jhin.2019.08.013>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10083685/3/Gurusamy%20Top%20research%20priorities.pdf