eprintid: 10083201
rev_number: 24
eprint_status: archive
userid: 608
dir: disk0/10/08/32/01
datestamp: 2019-10-10 11:55:42
lastmod: 2021-10-04 01:34:09
status_changed: 2020-03-09 10:21:47
type: article
metadata_visibility: show
creators_name: Vicente-Munuera, P
creators_name: Gómez-Gálvez, P
creators_name: Tetley, RJ
creators_name: Forja, C
creators_name: Tagua, A
creators_name: Letrán, M
creators_name: Tozluoglu, M
creators_name: Mao, Y
creators_name: Escudero, LM
title: EpiGraph: an open-source platform to quantify epithelial organization
ispublished: pub
divisions: UCL
divisions: B02
divisions: C08
divisions: D77
note: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
abstract: SUMMARY: Here we present EpiGraph, an image analysis tool that quantifies epithelial organization. Our method combines computational geometry and graph theory to measure the degree of order of any packed tissue. EpiGraph goes beyond the traditional polygon distribution analysis, capturing other organizational traits that improve the characterization of epithelia. EpiGraph can objectively compare the rearrangements of epithelial cells during development and homeostasis to quantify how the global ensemble is affected. Importantly, it has been implemented in the open-access platform Fiji. This makes EpiGraph very user friendly, with no programming skills required.
date: 2020-02-15
date_type: published
official_url: https://doi.org/10.1093/bioinformatics/btz683
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1700718
doi: 10.1093/bioinformatics/btz683
pii: 5564120
lyricists_name: Mao, Yanlan
lyricists_name: Tetley, Robert
lyricists_name: Vicente Munuera, Pablo
lyricists_id: YMAOX11
lyricists_id: RJTET59
lyricists_id: PVICE16
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Bioinformatics
volume: 36
number: 4
pagerange: 1314-1316
event_location: England
citation:        Vicente-Munuera, P;    Gómez-Gálvez, P;    Tetley, RJ;    Forja, C;    Tagua, A;    Letrán, M;    Tozluoglu, M;         ... Escudero, LM; + view all <#>        Vicente-Munuera, P;  Gómez-Gálvez, P;  Tetley, RJ;  Forja, C;  Tagua, A;  Letrán, M;  Tozluoglu, M;  Mao, Y;  Escudero, LM;   - view fewer <#>    (2020)    EpiGraph: an open-source platform to quantify epithelial organization.                   Bioinformatics , 36  (4)   pp. 1314-1316.    10.1093/bioinformatics/btz683 <https://doi.org/10.1093/bioinformatics%2Fbtz683>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10083201/1/btz683.pdf