<> <http://www.w3.org/2000/01/rdf-schema#comment> "The repository administrator has not yet configured an RDF license."^^<http://www.w3.org/2001/XMLSchema#string> . <> <http://xmlns.com/foaf/0.1/primaryTopic> <https://discovery.ucl.ac.uk/id/eprint/10083145> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/AcademicArticle> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Article> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://purl.org/dc/terms/title> "Higher dementia incidence in older adults with type 2 diabetes and large reduction in HbA1c"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://purl.org/ontology/bibo/abstract> "BACKGROUND: although type 2 diabetes increases risk of dementia by 2-fold, whether optimizing glycemic level in late life can reduce risk of dementia remains uncertain. We examined if achieving the glycemic goal recommended by the American Diabetes Association (ADA) within a year was associated with lower risk of dementia in 6 years. METHODS: in this population-based observational study, we examined 2246 community-living dementia-free Chinese older adults with type 2 diabetes who attended the Elderly Health Centres in Hong Kong at baseline and followed their HbA1c level and cognitive status for 6 years. In line with the ADA recommendation, we defined the glycemic goal as HbA1c < 7.5%. The study outcome was incident dementia in 6 years, diagnosed according to the 10th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD-10) or Clinical Dementia Rating of 1-3. RESULTS: those with HbA1c ≥ 7.5% at baseline and HbA1c < 7.5% in 1 year were associated with higher rather than lower incidence of dementia, independent of severe hypoglycemia, glycemic variability and other health factors. Sensitivity analyses showed that a relative reduction of ≥10%, but not 5-10%, in HbA1c within a year was associated with higher incidence of dementia in those with high (≥8%) and moderate (6.5-7.9%) HbA1c at baseline. CONCLUSION: a large reduction in HbA1c could be a potential predictor and possibly a risk factor for dementia in older adults with type 2 diabetes. Our findings suggest that optimizing or intensifying glycemic control in this population requires caution."^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://purl.org/dc/terms/date> "2019-11" . <https://discovery.ucl.ac.uk/id/document/1234084> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Document> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://purl.org/ontology/bibo/volume> "48" . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://purl.org/ontology/bibo/issue> "6" . <https://discovery.ucl.ac.uk/id/publication/ext-14682834> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://purl.org/ontology/bibo/Collection> . <https://discovery.ucl.ac.uk/id/publication/ext-14682834> <http://xmlns.com/foaf/0.1/name> "Age and Ageing"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://purl.org/dc/terms/isPartOf> 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<https://discovery.ucl.ac.uk/id/person/ext-648573cc0bc26f3ab79b0d8faeb3451d> <http://xmlns.com/foaf/0.1/name> "LCW Lam"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c737d73de2fa090c0585c1b546e13787> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-c737d73de2fa090c0585c1b546e13787> <http://xmlns.com/foaf/0.1/givenName> "WC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c737d73de2fa090c0585c1b546e13787> <http://xmlns.com/foaf/0.1/familyName> "Chan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-c737d73de2fa090c0585c1b546e13787> <http://xmlns.com/foaf/0.1/name> "WC Chan"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8b826d44028606e46dc2a74c1d6cf641> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-8b826d44028606e46dc2a74c1d6cf641> <http://xmlns.com/foaf/0.1/givenName> "M"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8b826d44028606e46dc2a74c1d6cf641> <http://xmlns.com/foaf/0.1/familyName> "Richards"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-8b826d44028606e46dc2a74c1d6cf641> <http://xmlns.com/foaf/0.1/name> "M Richards"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-01098cc7b213e1ba93154f154bc221ec> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-01098cc7b213e1ba93154f154bc221ec> <http://xmlns.com/foaf/0.1/givenName> "RSY"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-01098cc7b213e1ba93154f154bc221ec> <http://xmlns.com/foaf/0.1/familyName> "Lee"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-01098cc7b213e1ba93154f154bc221ec> <http://xmlns.com/foaf/0.1/name> "RSY Lee"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-368a3bc8db84c51073747623a6c6c6f5> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-368a3bc8db84c51073747623a6c6c6f5> <http://xmlns.com/foaf/0.1/givenName> "HFK"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-368a3bc8db84c51073747623a6c6c6f5> <http://xmlns.com/foaf/0.1/familyName> "Chiu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-368a3bc8db84c51073747623a6c6c6f5> <http://xmlns.com/foaf/0.1/name> "HFK Chiu"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9dfb2266581882ffdbee5f04c3024198> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://xmlns.com/foaf/0.1/Person> . <https://discovery.ucl.ac.uk/id/person/ext-9dfb2266581882ffdbee5f04c3024198> <http://xmlns.com/foaf/0.1/givenName> "ATC"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9dfb2266581882ffdbee5f04c3024198> <http://xmlns.com/foaf/0.1/familyName> "Lee"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/person/ext-9dfb2266581882ffdbee5f04c3024198> <http://xmlns.com/foaf/0.1/name> "ATC Lee"^^<http://www.w3.org/2001/XMLSchema#string> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/EPrint> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://eprints.org/ontology/ArticleEPrint> . <https://discovery.ucl.ac.uk/id/eprint/10083145> <http://purl.org/dc/terms/isPartOf> <https://discovery.ucl.ac.uk/id/repository> . <https://discovery.ucl.ac.uk/id/eprint/10083145> 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