eprintid: 10083047
rev_number: 21
eprint_status: archive
userid: 608
dir: disk0/10/08/30/47
datestamp: 2019-10-09 16:23:51
lastmod: 2021-12-13 23:28:00
status_changed: 2019-10-09 16:23:51
type: article
metadata_visibility: show
creators_name: Macerollo, A
creators_name: Limousin, P
creators_name: Korlipara, P
creators_name: Foltynie, T
creators_name: Edwards, MJ
creators_name: Kilner, J
title: Dopaminergic Modulation of Sensory Attenuation in Parkinson's Disease: Is There an Underlying Modulation of Beta Power?
ispublished: pub
subjects: UCH
divisions: UCL
divisions: B02
divisions: C07
divisions: D07
divisions: F84
keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Parkinson's disease, sensory attenuation, beta power, bradykinesia, motor symptoms, SOMATOSENSORY-EVOKED-POTENTIALS, FREQUENCY STIMULATION, SUBTHALAMIC NUCLEUS, ACTIVE INFERENCE, MOVEMENT, OSCILLATIONS, SUPPRESSION, REDUCTION, FRAMEWORK, CORTEX
note: This work is licensed under a Creative Commons Attribution 4.0 International License. The images
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unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license,
users will need to obtain permission from the license holder to reproduce the material. To view a copy of this
license, visit http://creativecommons.org/licenses/by/4.0/
abstract: Background and Aims: Pathological high amplitude of beta oscillations is thought as
the underlying mechanism of motor symptoms in Parkinson’s disease (PD), in particular
with regard to bradykinesia. In addition, abnormality in a neurophysiological phenomenon
labeled sensory attenuation has been found in patients with PD. The current study
explored the hypothesis that the abnormal sensory attenuation has a causal link with
the typical abnormality in beta oscillations in PD.
Methods: The study tested sixteen right-handed patients with a diagnosis of PD and 22
healthy participants, which were matched by age and gender. Somatosensory evoked
potentials were elicited through electrical stimulation of the median nerve at the wrist.
Electrical activity was recorded at the scalp using a 128 channels EEG. Somatosensory
evoked potentials were recorded in 2 conditions: at rest and at the onset of a voluntary
movement, which was a self-paced abduction movement of the right thumb.
Results: Healthy participants showed a reduction of the N20-P25 amplitude at the
onset of the right thumb abduction compared to the rest condition (P < 0.05). When
patients were OFF medication, they showed mild reduction of the N20-P25 component
at movement onset (P < 0.05). On the contrary, they did show greater attenuation of the
N20-P25 component at the onset ofmovement compared to the rest condition when ON
medication (P < 0.05). There was no significant evidence of a link between the degree
of sensory attenuation and the change in beta oscillations in our cohort of patients.
Conclusion: These results confirmed a significant link between dopaminergic
modulation and sensory attenuation. However, the sensory attenuation and beta
oscillations were found as two independent phenomena.
date: 2019-09-18
date_type: published
publisher: FRONTIERS MEDIA SA
official_url: https://doi.org/10.3389/fneur.2019.01001
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
article_type_text: Article
verified: verified_manual
elements_id: 1700813
doi: 10.3389/fneur.2019.01001
lyricists_name: Foltynie, Thomas
lyricists_name: Kilner, James
lyricists_name: Limousin, Patricia
lyricists_id: TFOLT83
lyricists_id: JMKIL68
lyricists_id: PDLIM44
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Frontiers in Neurology
volume: 10
article_number: 1001
pages: 14
issn: 1664-2295
citation:        Macerollo, A;    Limousin, P;    Korlipara, P;    Foltynie, T;    Edwards, MJ;    Kilner, J;      (2019)    Dopaminergic Modulation of Sensory Attenuation in Parkinson's Disease: Is There an Underlying Modulation of Beta Power?                   Frontiers in Neurology , 10     , Article 1001.  10.3389/fneur.2019.01001 <https://doi.org/10.3389/fneur.2019.01001>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10083047/1/fneur-10-01001.pdf