%T Dopaminergic Modulation of Sensory Attenuation in Parkinson's Disease: Is There an Underlying Modulation of Beta Power?
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%D 2019
%L discovery10083047
%I FRONTIERS MEDIA SA
%J Frontiers in Neurology
%X Background and Aims: Pathological high amplitude of beta oscillations is thought as
the underlying mechanism of motor symptoms in Parkinson’s disease (PD), in particular
with regard to bradykinesia. In addition, abnormality in a neurophysiological phenomenon
labeled sensory attenuation has been found in patients with PD. The current study
explored the hypothesis that the abnormal sensory attenuation has a causal link with
the typical abnormality in beta oscillations in PD.
Methods: The study tested sixteen right-handed patients with a diagnosis of PD and 22
healthy participants, which were matched by age and gender. Somatosensory evoked
potentials were elicited through electrical stimulation of the median nerve at the wrist.
Electrical activity was recorded at the scalp using a 128 channels EEG. Somatosensory
evoked potentials were recorded in 2 conditions: at rest and at the onset of a voluntary
movement, which was a self-paced abduction movement of the right thumb.
Results: Healthy participants showed a reduction of the N20-P25 amplitude at the
onset of the right thumb abduction compared to the rest condition (P < 0.05). When
patients were OFF medication, they showed mild reduction of the N20-P25 component
at movement onset (P < 0.05). On the contrary, they did show greater attenuation of the
N20-P25 component at the onset ofmovement compared to the rest condition when ON
medication (P < 0.05). There was no significant evidence of a link between the degree
of sensory attenuation and the change in beta oscillations in our cohort of patients.
Conclusion: These results confirmed a significant link between dopaminergic
modulation and sensory attenuation. However, the sensory attenuation and beta
oscillations were found as two independent phenomena.
%V 10
%A A Macerollo
%A P Limousin
%A P Korlipara
%A T Foltynie
%A MJ Edwards
%A J Kilner
%K Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Parkinson's disease, sensory attenuation, beta power, bradykinesia, motor symptoms, SOMATOSENSORY-EVOKED-POTENTIALS, FREQUENCY STIMULATION, SUBTHALAMIC NUCLEUS, ACTIVE INFERENCE, MOVEMENT, OSCILLATIONS, SUPPRESSION, REDUCTION, FRAMEWORK, CORTEX