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<https://discovery.ucl.ac.uk/id/eprint/10083047> <http://purl.org/dc/terms/title> "Dopaminergic Modulation of Sensory Attenuation in Parkinson's Disease: Is There an Underlying Modulation of Beta Power?"^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10083047> <http://purl.org/ontology/bibo/abstract> "Background and Aims: Pathological high amplitude of beta oscillations is thought as\r\nthe underlying mechanism of motor symptoms in Parkinson’s disease (PD), in particular\r\nwith regard to bradykinesia. In addition, abnormality in a neurophysiological phenomenon\r\nlabeled sensory attenuation has been found in patients with PD. The current study\r\nexplored the hypothesis that the abnormal sensory attenuation has a causal link with\r\nthe typical abnormality in beta oscillations in PD.\r\nMethods: The study tested sixteen right-handed patients with a diagnosis of PD and 22\r\nhealthy participants, which were matched by age and gender. Somatosensory evoked\r\npotentials were elicited through electrical stimulation of the median nerve at the wrist.\r\nElectrical activity was recorded at the scalp using a 128 channels EEG. Somatosensory\r\nevoked potentials were recorded in 2 conditions: at rest and at the onset of a voluntary\r\nmovement, which was a self-paced abduction movement of the right thumb.\r\nResults: Healthy participants showed a reduction of the N20-P25 amplitude at the\r\nonset of the right thumb abduction compared to the rest condition (P < 0.05). When\r\npatients were OFF medication, they showed mild reduction of the N20-P25 component\r\nat movement onset (P < 0.05). On the contrary, they did show greater attenuation of the\r\nN20-P25 component at the onset ofmovement compared to the rest condition when ON\r\nmedication (P < 0.05). There was no significant evidence of a link between the degree\r\nof sensory attenuation and the change in beta oscillations in our cohort of patients.\r\nConclusion: These results confirmed a significant link between dopaminergic\r\nmodulation and sensory attenuation. However, the sensory attenuation and beta\r\noscillations were found as two independent phenomena."^^<http://www.w3.org/2001/XMLSchema#string> .
<https://discovery.ucl.ac.uk/id/eprint/10083047> <http://purl.org/dc/terms/date> "2019-09-18" .
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