%0 Journal Article
%@ 1664-2295
%A Macerollo, A
%A Limousin, P
%A Korlipara, P
%A Foltynie, T
%A Edwards, MJ
%A Kilner, J
%D 2019
%F discovery:10083047
%I FRONTIERS MEDIA SA
%J Frontiers in Neurology
%K Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences, Neurosciences & Neurology, Parkinson's disease, sensory attenuation, beta power, bradykinesia, motor symptoms, SOMATOSENSORY-EVOKED-POTENTIALS, FREQUENCY STIMULATION, SUBTHALAMIC NUCLEUS, ACTIVE INFERENCE, MOVEMENT, OSCILLATIONS, SUPPRESSION, REDUCTION, FRAMEWORK, CORTEX
%T Dopaminergic Modulation of Sensory Attenuation in Parkinson's Disease: Is There an Underlying Modulation of Beta Power?
%U https://discovery.ucl.ac.uk/id/eprint/10083047/
%V 10
%X Background and Aims: Pathological high amplitude of beta oscillations is thought as  the underlying mechanism of motor symptoms in Parkinson’s disease (PD), in particular  with regard to bradykinesia. In addition, abnormality in a neurophysiological phenomenon  labeled sensory attenuation has been found in patients with PD. The current study  explored the hypothesis that the abnormal sensory attenuation has a causal link with  the typical abnormality in beta oscillations in PD.  Methods: The study tested sixteen right-handed patients with a diagnosis of PD and 22  healthy participants, which were matched by age and gender. Somatosensory evoked  potentials were elicited through electrical stimulation of the median nerve at the wrist.  Electrical activity was recorded at the scalp using a 128 channels EEG. Somatosensory  evoked potentials were recorded in 2 conditions: at rest and at the onset of a voluntary  movement, which was a self-paced abduction movement of the right thumb.  Results: Healthy participants showed a reduction of the N20-P25 amplitude at the  onset of the right thumb abduction compared to the rest condition (P < 0.05). When  patients were OFF medication, they showed mild reduction of the N20-P25 component  at movement onset (P < 0.05). On the contrary, they did show greater attenuation of the  N20-P25 component at the onset ofmovement compared to the rest condition when ON  medication (P < 0.05). There was no significant evidence of a link between the degree  of sensory attenuation and the change in beta oscillations in our cohort of patients.  Conclusion: These results confirmed a significant link between dopaminergic  modulation and sensory attenuation. However, the sensory attenuation and beta  oscillations were found as two independent phenomena.
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