eprintid: 10082709
rev_number: 27
eprint_status: archive
userid: 608
dir: disk0/10/08/27/09
datestamp: 2019-10-03 11:47:03
lastmod: 2021-09-25 23:22:21
status_changed: 2020-06-10 10:55:36
type: article
metadata_visibility: show
creators_name: Pallares, RM
creators_name: Thanh, NTK
creators_name: Su, X
title: Sensing of circulating cancer biomarkers with metal nanoparticles
ispublished: pub
divisions: UCL
divisions: B04
divisions: C06
divisions: F60
note: This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.  https://creativecommons.org/licenses/by/3.0/
abstract: The analysis of circulating cancer biomarkers, including cell-free and circulating tumor DNA, circulating
tumor cells, microRNA and exosomes, holds promise in revolutionizing cancer diagnosis and prognosis
using body fluid analysis, also known as liquid biopsy. To enable clinical application of these biomarkers,
new analytical tools capable of detecting them in very low concentrations in complex sample matrixes
are needed. Metal nanoparticles have emerged as extraordinary analytical scaffolds because of their
unique optoelectronic properties and ease of functionalization. Hence, multiple analytical techniques
have been developed based on these nanoparticles and their plasmonic properties. The aim of this review
is to summarize and discuss the present development on the use of metal nanoparticles for the analysis
of circulating cancer biomarkers. We examine how metal nanoparticles can be used as (1) analytical transducers in various sensing principles, such as aggregation induced colorimetric assays, plasmon resonance
energy transfer, surface enhanced Raman spectroscopy, and refractive index sensing, and (2) signal
amplification elements in surface plasmon resonance spectroscopy and electrochemical detection. We
critically discuss the clinical relevance of each category of circulating biomarkers, followed by a thorough
analysis of how these nanoparticle-based designs have overcome some of the main challenges that gold
standard analytical techniques currently face, and what new directions the field may take in the future.
date: 2019-12-14
date_type: published
official_url: https://doi.org/10.1039/c9nr03040a
oa_status: green
full_text_type: pub
language: eng
primo: open
primo_central: open_green
verified: verified_manual
elements_id: 1697663
doi: 10.1039/c9nr03040a
lyricists_name: Nguyen, Thanh
lyricists_id: TTKNG00
actors_name: Flynn, Bernadette
actors_id: BFFLY94
actors_role: owner
full_text_status: public
publication: Nanoscale
volume: 11
number: 46
pagerange: 22152-22171
event_location: England
issn: 2040-3372
citation:        Pallares, RM;    Thanh, NTK;    Su, X;      (2019)    Sensing of circulating cancer biomarkers with metal nanoparticles.                   Nanoscale , 11  (46)   pp. 22152-22171.    10.1039/c9nr03040a <https://doi.org/10.1039/c9nr03040a>.       Green open access   
 
document_url: https://discovery.ucl.ac.uk/id/eprint/10082709/7/Nguyen_c9nr03040a.pdf